120958-90-9
120958-90-9
Chemical Structure
Dalcotidine
Synonym(s): KU-1257
- CAS 番号: 120958-90-9
- Formula:C18H29N3O2
- Molecular Weight:319.44
IUPAC Name: 1-ethyl-3-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)urea
InChIKey: SVCQBXMFONNZHX-UHFFFAOYSA-N
SMILES: O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)NCC
Biological Activity: Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion[1][2].
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Dalcotidine | Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion. | |||||||||||||||||||||
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References
- [1]. Sekiguchi H, et al. Healing-promoting action of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]urea with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats. Arzneimittelforschung. 1993;43(2):139-143. [Content Brief]
- [2]. Sekiguchi H, et al. Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats. Arzneimittelforschung. 1993;43(2):134-138. [Content Brief]
