SYCP3 Antibody (YA5157)

Cat. No.: HY-P85465: Ficha de datos User Guide for Antibodies
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SYCP3 Antibody (YA5157) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYCP3.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

SYCP3 Antibody (YA5157) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYCP3.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 28 kDa;

Species Reactivity

Human

SwissProt ID

Q8IZU3

Gene ID

50511 [NCBI]

Immunogen

Purified recombinant human SCP-3 protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000

Conjugation	Non-conjugated	Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity)

Subcellular Localization：Nucleus; Chromosome; Chromosome, centromere

Expression：
Tissue_specificity:Testicular specificity

Subunit：Component of the lateral elements of synaptonemal complexes (By similarity). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (PubMed:24950965). Interacts with SYCP2 (By similarity). Forms a complex with EWSR1, PRDM9, REC8 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity)

Synonyms

SYCP3; SCP3; Synaptonemal complex protein 3; SCP-3

Documentación

User Guide for Antibodies (1077 KB)