SYCP3 - synaptonemal complex protein 3 Gene

Also Known as COR1; SCP3; SPGF4; RPRGL4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50511

About SYCP3

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,728,648-101,739,462 (from NCBI)

This gene has 5 transcripts (splice variants), 327 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 35.2), duodenum (RPKM 4.0) and 14 other tissues.

Summary

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

SYCP3 Products (3)

mRNA	Protein	Name
NM_001177948.2	NP_001171419.1	synaptonemal complex protein 3
NM_001177949.2	NP_001171420.1	synaptonemal complex protein 3
NM_153694.5	NP_710161.1	synaptonemal complex protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	14643120	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	22899867	GOA
located in synaptonemal complex	IDA IDA: Inferred from direct assay	9774970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYCP3 Protein Structure

Cor1

0
100
200
236 a.a.

Protein Preferred Names	Protein Names
synaptonemal complex protein 3

SYCP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYCP3	Q8IZU3	BLK	Homo sapiens	P51451	Anti Tag CoIP	33961781
Intra	SYCP3	Q8IZU3	BLK	Homo sapiens	P51451	Anti Tag CoIP	28514442
Intra	SYCP3	Q8IZU3	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	SYCP3	Q8IZU3	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SYCP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84668	SYCP3 Antibody (YA4365)	IHC-P, FC, ELISA	Human
HY-P84668A	SYCP3 Antibody (YA4365)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85465	SYCP3 Antibody (YA5157)	WB	Human

Related Diseases

Diseases	Alias
Spermatogenic Failure 4	Spermatogenesis Arrest SPGF4 Azoospermia Due To Perturbations Of Meiosis Azoospermia With Maturation Arrest Pregnancy Loss, Recurrent, 4 Arrest Of Spermatogenesis RPRGL4 Recurrent Pregnancy Loss 4
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Branchiootorenal Syndrome 2	BOR2 Bor Syndrome 2 Branchiootorenal Dysplasia 2 Branchio-Oto-Renal Dysplasia 2 Branchio-Oto-Renal Syndrome Type 2 Branchiootorenal Syndrome, Type 2
Infertility
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Gemistocytic Astrocytoma	Gemistocytic Astrocytic Tumor
Autoimmune Cardiomyopathy
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Oligospermia
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14072	SYCP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21776	Sycp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28293	Sycp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYCP3	MGD	MGI:109542
Rattus norvegicus	SYCP3	RGD	RGD:3795
Bos taurus	SYCP3	VGNC	VGNC:56229
Others	SYCP3	NCBI