HTR2C - 5-hydroxytryptamine receptor 2C Gene

Also Known as HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3358

About HTR2C

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:114,584,086-114,910,061 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and 8 paralogues. Restricted expression toward brain (RPKM 1.3).

Summary

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

HTR2C Products (3)

mRNA	Protein	Name
NM_000868.4	NP_000859.2	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256760.3	NP_001243689.2	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256761.3	NP_001243690.2	5-hydroxytryptamine receptor 2C isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	IDA IDA: Inferred from direct assay	19057895	GOA
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7582481	GOA
enables Gq/11-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	18703043	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15518545	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14988405	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	7582481	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	29398112	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	18703043	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12970106	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	19057895	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	12970106	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19057895	GOA
involved in positive regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	19057895	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	18703043	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of G protein-coupled serotonin receptor complex	IDA IDA: Inferred from direct assay	12970106	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12970106	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18703043	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR2C Protein Structure

7tm_1

0
100
200
300
400
458 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

HTR2C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HTR2C	P28335	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	HTR2C	P28335	MTNR1B	Homo sapiens	P49286	BRET	25770211
Intra	HTR2C	P28335	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Anti Tag CoIP	33961781
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Anti Tag CoIP	28514442
Intra	HTR2C	P28335	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	HTR2C	P28335	HTR2A	Homo sapiens	P28223	PLA	30157263
Intra	HTR2C	P28335	HTR2A	Homo sapiens	P28223	BRET	30157263
Intra	HTR2C	P28335	HTR2B	Homo sapiens	P41595	BRET	28258217
Intra	HTR2C	P28335	HTR2B	Homo sapiens	P41595	Anti Tag CoIP	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Anti Tag CoIP	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	25770211
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	FRET	16195233
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Crosslink	16195233
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	FRET	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Crosslink	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Confocal	16195233

Cross: Cross-species interaction Intra: Intraspecies interaction

HTR2C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811130	5-HT2C Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Dog
HY-P83619	HTR2C Antibody (YA3364)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Premature Ejaculation
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Borderline Personality Disorder
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Hyperprolactinemia	Chiari-Frommel Syndrome Hyperprolactinaemia Familial Hyperprolactinemia HPRL Pregnancy-Related A-G Syndrome Familial Isolated Prolactin Receptor Deficiency
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos
Generalized Anxiety Disorder	Anxiety Generalized
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Psychosexual Disorder	Psychosexual Disorders
Delusional Disorder	Persistent Delusional Disorders Delusional Perception Induced Delusional Disorder
Mood Disorder	Mood Disorders Episodic Mood Disorder
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Inhibited Male Orgasm	Male Orgasmic Disorder Psychosexual Dysfunction With Male Orgasmic Disorder
Sexual Health Disorder	Sexual Health
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Sleep Apnea	Sleep Apnea Syndromes
High Pressure Neurological Syndrome
Lingual-Facial-Buccal Dyskinesia	Orofacial Dyskinesia Oro-Facial Dyskinesia Dyskinesias
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Hypoactive Sexual Desire Disorder	Lack Or Loss Of Sexual Desire Sexual Dysfunctions, Psychological
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Neurotic Disorder	Neurosis Reactive Depression Adjustment Disorders Neurotic Disorders Depressive Neurosis Neurotic Depression Neurotic Depression Reactive Type Neurotic Depressive State Psychoneurosis Depressive Disorder Depression, Neurotic
Mental Depression	Depression Depressive Disorder
Paranoid Schizophrenia	Chronic Paranoid Schizophrenia Paranoid Type Schizophrenia Paranoid Type Schizophrenia Subchronic State Paraphrenia - Late Paraphrenic Schizophrenia Schizophrenia, Paranoid
Intermittent Explosive Disorder	Explosive Personality Disorder
Schizophreniform Disorder	Schizophreniform Disorders Psychotic Disorders
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Drug Psychosis	Drug-Induced Psychosis Drug-Induced Psychotic Disorder Psychoses, Substance-Induced Psychoses, Drug
Drug-Induced Mental Disorder
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Substance-Induced Psychosis
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Disease Of Mental Health	Mental Health Mental Disorders
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06469	HTR2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20957	Htr2c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27474	Htr2c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTR2C	RGD	RGD:2848
Canis familiaris	HTR2C	VGNC	VGNC:41828
Macaca mulatta	HTR2C	VGNC	VGNC:73541
Mus musculus	HTR2C	MGD	MGI:96281
Others	HTR2C	NCBI