HTR2B - 5-hydroxytryptamine receptor 2B Gene

Also Known as 5-HT2B; 5-HT-2B; 5-HT(2B)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3357

About HTR2B

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,108,230-231,125,042 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 8 paralogues. Biased expression in endometrium (RPKM 10.3), adrenal (RPKM 7.1) and 8 other tissues.

Summary

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, Other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

HTR2B Products (2)

mRNA	Protein	Name
NM_000867.5	NP_000858.3	5-hydroxytryptamine receptor 2B isoform 1
NM_001320758.2	NP_001307687.1	5-hydroxytryptamine receptor 2B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7582481	GOA
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	15625277	GOA
enables G-protein alpha-subunit binding	IMP IMP: Inferred from mutant phenotype	15625277	GOA
enables Gq/11-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	18703043	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28258217	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	7582481	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	30127358	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19308295	GOA
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15625277	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	7926008	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18703043	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12970106	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	8882600	GOA
involved in intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	7599919	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	19057895	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	12970106	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20099302	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19057895	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15625277	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15925089	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	19023134	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19308295	GOA
involved in positive regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	19057895	GOA
involved in regulation of behavior	IMP IMP: Inferred from mutant phenotype	21179162	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15862800	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	8882600	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	15862800	GOA
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	15625277	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of G protein-coupled serotonin receptor complex	IDA IDA: Inferred from direct assay	7926008	GOA
part of G protein-coupled serotonin receptor complex	IMP IMP: Inferred from mutant phenotype	15625277	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15925089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7926008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR2B Protein Structure

7tm_1

0
100
200
300
400
481 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 2B	5-HT 2B receptor

HTR2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HTR2B	P41595	HTR2A	Homo sapiens	P28223	BRET	28258217
Intra	HTR2B	P41595	HTR2C	Homo sapiens	P28335	BRET	28258217

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Hypoactive Sexual Desire Disorder	Lack Or Loss Of Sexual Desire Sexual Dysfunctions, Psychological
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Chronic Pulmonary Heart Disease
Intermittent Explosive Disorder	Explosive Personality Disorder
Pulmonary Valve Insufficiency	Pulmonary Regurgitation Pulmonary Incompetence Pulmonary Incompetence, Non-Rheumatic Pulmonary Insufficiency Following Trauma And Surgery Pulmonary Regurg. Pulmonic Insufficiency Pulmonic Valve Regurgitation Pulmonary Valve Incompetence Pulmonary Valve Incompetency Pulmonary Valvular Insufficiency Pulmonary Valvular Regurgitation Pulmonary Valvular Incompetency Pulmonary Valve Incompetence Nos Annular Incompetency Pulmonary Valve Incompetent Pulmonary Valve Graham Steell Murmur Pulmonary Valvular Incompetence
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169229	GM-60186	Inhibitor	99.34%	Unkown
HY-RS06468	HTR2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19011	Htr2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25500	Htr2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTR2B	RGD	RGD:61801
Bos taurus	HTR2B	VGNC	VGNC:29997
Macaca mulatta	HTR2B	VGNC	VGNC:73540
Felis catus	HTR2B	VGNC	VGNC:67672
Canis familiaris	HTR2B	VGNC	VGNC:41827
Mus musculus	HTR2B	MGD	MGI:109323
Others	HTR2B	NCBI