TMBIM6 - transmembrane BAX inhibitor motif containing 6 Gene

Homo sapiens

Also known as BI-1; TEGT; BAXI1

Gene ID: 7009 | Gene type: protein coding

About TMBIM6

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,741,557-49,764,934 (from NCBI)

This gene has 28 transcripts (splice variants), 251 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 392.9), liver (RPKM 352.7) and 25 other tissues.

Summary

Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM6 Products(2)

mRNA	Protein	Name
NM_001098576.2	NP_001092046.1	bax inhibitor 1 isoform 2
NM_003217.3	NP_003208.2	bax inhibitor 1 isoform 1

TMBIM6 Protein Structure

Bax1-I

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

bax inhibitor 1

testis enhanced gene transcript

Related Diseases

Diseases

Alias

Chronic Congestive Splenomegaly

Hypoglycemia, Leucine-Induced

Leucine-Sensitive Hypoglycemia Of Infancy	Leucine-Induced Hypoglycemia
LIH	Hypoglycemia Of Infancy, Leucine-Sensitive
Familial Infantile Hypoglycemia Precipitated By Leucine	Hypoglycemia Leucine Induced
Hypoglycemia Leucine-Induced

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137175	TMBIM6 antagonist-1	Antagonist	99.60%	Unkown
HY-161388	NSCLC-IN-1	Inducer	/	Unkown
HY-RS14620	TMBIM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMBIM6	VGNC	VGNC:66233
Canis familiaris	TMBIM6	VGNC	VGNC:47419
Macaca mulatta	TMBIM6	VGNC	VGNC:107118
Bos taurus	TMBIM6	VGNC	VGNC:35916
Rattus norvegicus	TMBIM6	RGD	RGD:3842
Mus musculus	TMBIM6	MGD	MGI:99682

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