CDC7 - cell division cycle 7 Gene

Homo sapiens

Also known as Hsk1; CDC7L1; HsCDC7; huCDC7

Gene ID: 8317 | Gene type: protein coding

About CDC7

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,500,851-91,525,764 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues.

Summary

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

CDC7 Products(3)

mRNA	Protein	Name
NM_001134419.2	NP_001127891.1	cell division cycle 7-related protein kinase
NM_001134420.2	NP_001127892.1	cell division cycle 7-related protein kinase
NM_003503.4	NP_003494.1	cell division cycle 7-related protein kinase

CDC7 Protein Structure

Pkinase

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

cell division cycle 7-related protein kinase

CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1

Related Diseases

Diseases

Alias

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100888	Simurosertib		99.07%	Phase 2
HY-143430A	(S)-LY3177833 hydrate	Inhibitor	/	Phase 1
HY-143430	(S)-LY3177833	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15260A	XL413 monohydrochloride	Inhibitor	99.72%	Unkown
HY-13461A	PHA-767491 hydrochloride		98.06%	Unkown
HY-133028	CKI-7 free base	Inhibitor	99.34%	Unkown
HY-100023	LY3177833	Inhibitor	99.48%	Unkown
HY-100888A	(R)-Simurosertib		98.07%	Unkown
HY-130517	Cdc7-IN-5	Inhibitor	96.73%	Unkown
HY-101523	Cdc7-IN-1	Inhibitor	99.77%	Unkown
HY-100023A	LY3177833 monhydrate	Inhibitor	99.76%	Unkown
HY-13461	PHA-767491	Inhibitor	/	Unkown
HY-15260	XL413	Inhibitor	/	Unkown
HY-130516	Cdc7-IN-4	Inhibitor	/	Unkown
HY-130515	Cdc7-IN-3	Inhibitor	/	Unkown
HY-130519	Cdc7-IN-7	Inhibitor	/	Unkown
HY-143377	Cdc7-IN-8	Inhibitor	/	Unkown
HY-143380	Cdc7-IN-9	Inhibitor	/	Unkown
HY-143381	Cdc7-IN-10	Inhibitor	/	Unkown
HY-143383	Cdc7-IN-11	Inhibitor	/	Unkown
HY-143385	Cdc7-IN-12	Inhibitor	/	Unkown
HY-143387	Cdc7-IN-13	Inhibitor	/	Unkown
HY-143389	Cdc7-IN-14	Inhibitor	/	Unkown
HY-143429	Cdc7-IN-15	Inhibitor	/	Unkown
HY-143431	Cdc7-IN-17	Inhibitor	/	Unkown
HY-143432	Cdc7-IN-18	Inhibitor	/	Unkown
HY-143432A	(S)-Cdc7-IN-18	Inhibitor	/	Unkown
HY-143433	Cdc7-IN-19	Inhibitor	/	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-15260C	XL413 hydrochloride	Inhibitor	/	Unkown
HY-162007	PYRA-2	Inhibitor	/	Unkown
HY-163374	Cdc7-IN-20	Inhibitor	/	Unkown
HY-RS02309	CDC7 Human Pre-designed siRNA Set A		/	Unkown
HY-W011109	CKI-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC7	VGNC	VGNC:80164
Mus musculus	CDC7	MGD	MGI:1309511
Canis familiaris	CDC7	VGNC	VGNC:39010
Macaca mulatta	CDC7	VGNC	VGNC:106340
Rattus norvegicus	CDC7	RGD	RGD:1308351
Bos taurus	CDC7	VGNC	VGNC:27082

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