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(R)-Simurosertib (Synonyms: (R)-TAK-931)

Cat. No.: HY-100888A Purity: 99.44% ee.: 98.65%
Handling Instructions

(R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib, Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM.

For research use only. We do not sell to patients.

(R)-Simurosertib Chemical Structure

(R)-Simurosertib Chemical Structure

CAS No. : 1330782-69-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 244 In-stock
Estimated Time of Arrival: December 31
2 mg USD 130 In-stock
Estimated Time of Arrival: December 31
5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

(R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib, Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM[1].

Molecular Weight

341.43

Formula

C₁₇H₁₉N₅OS

CAS No.

1330782-69-8

SMILES

O=C(C1=C(N2)C=C(C3=CNN=C3C)S1)N=C2[[email protected]]4CC5CCN4CC5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (219.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9289 mL 14.6443 mL 29.2886 mL
5 mM 0.5858 mL 2.9289 mL 5.8577 mL
10 mM 0.2929 mL 1.4644 mL 2.9289 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(R)-Simurosertib
Cat. No.:
HY-100888A
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