LY3177833 monhydrate
LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer.
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- No. CAS: 1627696-53-0
- Fòrmula: C16H14FN5O2
- Peso molecular:327.31
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Cdc7 3.3 nM (IC50) |
pMCM2 290 nM (IC50) |
In Vitro
LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hep3B cells
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Concentration:10 μM
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Incubation Time:4 days
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Result:Increased the expression of human SA-β-gal.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
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Dosage:10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
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Administration:Oral gavage; twice a day for 2 weeks
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Result:Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.
Chemical Information
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No. CAS 1627696-53-0
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Appearance Solid
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Peso molecular 327.31
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Fòrmula C16H14FN5O2
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Color White to off-white
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SMILES
O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3.[H]O[H]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3177833 monhydrate Related Classifications
HY-100023A Related Classifications
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