2. Cell Cycle/DNA Damage
  3. CDK
  4. LY3177833 monhydrate

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer.

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LY3177833 monhydrate Chemical Structure

LY3177833 monhydrate Chemical Structure

CAS No. : 1627696-53-0

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LY3177833 monhydrate Related Antibodies

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Description

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].

IC50 & Target[1]

Cdc7

3.3 nM (IC50)

pMCM2

290 nM (IC50)

In Vitro

LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY3177833 monhydrate Related Antibodies

Western Blot Analysis[2]

Cell Line: Hep3B cells
Concentration: 10 μM
Incubation Time: 4 days
Result: Increased the expression of human SA-β-gal.
In Vivo

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
Dosage: 10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration: Oral gavage; twice a day for 2 weeks
Result: Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.
Molecular Weight

327.31

Formula

C16H14FN5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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LY3177833 monhydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY3177833 monhydrate1627696-53-0CDKCyclin dependent kinasepMCM2Hep3SA-β-galSW620Inhibitorinhibitorinhibit

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