1. Cell Cycle/DNA Damage
  2. CDK
  3. LY3177833

LY3177833 

Cat. No.: HY-100023 Purity: 99.78%
Handling Instructions

LY3177833 is a CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.

For research use only. We do not sell to patients.

LY3177833 Chemical Structure

LY3177833 Chemical Structure

CAS No. : 1627696-51-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 768 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LY3177833 is a CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively[1].

IC50 & Target[1]

Cdc7

3.3 nM (IC50)

In Vivo

LY3177833 (Compound example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dosedependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
Dosage: 10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration: Oral gavage; twice a day; for 2 weeks
Result: Dose dependent antitumor activity in SW620 mouse xenograft tumor model.
Molecular Weight

309.30

Formula

C₁₆H₁₂FN₅O

CAS No.

1627696-51-8

SMILES

O=C1N[[email protected]@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (96.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2331 mL 16.1655 mL 32.3311 mL
5 mM 0.6466 mL 3.2331 mL 6.4662 mL
10 mM 0.3233 mL 1.6166 mL 3.2331 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LY3177833LY 3177833LY-3177833CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product Name:
LY3177833
Cat. No.:
HY-100023
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