2. Cell Cycle/DNA Damage
  3. CDK
  4. Cdc7-IN-20

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC50 and Ki values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity.

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Cdc7-IN-20 Chemical Structure

Cdc7-IN-20 Chemical Structure

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Cdc7-IN-20 Related Antibodies

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Description

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC50 and Ki values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity[1].

In Vitro

Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) can inhibit the proliferation of COLO 205 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cdc7-IN-20 Related Antibodies

Western Blot Analysis[1]

Cell Line: COLO 205
Concentration: 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Inhibited the phosphorylation at Ser53 and Ser40 of MCM2 in a dose-dependent manner.
In Vivo

Cdc7-IN-20 (2, 4, 8 mg/kg, orally, for 3 consecutive days) has an antitumor effect in COLO 205 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: COLO 205 xenograft mice model[1]
Dosage: 2, 4, 8 mg/kg
Administration: p.o. for 3 consecutive days
Result: Inhibit the expression of p-MCM2 protein.
Molecular Weight

300.38

Formula

C15H16N4OS
SMILES

O=C1NC(C(N)C(C)C)=NC2=C1SC(C3=CC=NC=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cdc7-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cdc7-IN-20CDKCyclin dependent kinaseCdc7InhibitorCOLO 205 cellsAntitumorinhibitorinhibit

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