Cdc7-IN-21
Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC50 of 0.07 nM. Cdc7-IN-21 can be used to study cancer.
For research use only. We do not sell to patients.
- CAS No.: 1330781-04-8
- Formula: C15H17N5OS
- Molecular Weight:315.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | EC50 |
1100 nM
Compound: 10c
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Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay
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[PMID: 28533114] |
| COLO 205 | EC50 |
1100 nM
Compound: Cpd I
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Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay
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[PMID: 31895562] |
| HeLa | IC50 |
250 nM
Compound: 10c
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Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis
Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis
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[PMID: 28533114] |
| HeLa | IC50 |
250 nM
Compound: Cpd I
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Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis
Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis
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[PMID: 31895562] |
Chemical Information
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CAS No. 1330781-04-8
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Molecular Weight 315.39
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Formula C15H17N5OS
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SMILES
O=C1N=C(CN2CCCC2)NC3=C1SC(C4=CNN=C4C)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cdc7-IN-21 Related Classifications
HY-117677 Related Classifications
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