SLAMF6 - SLAM family member 6 Gene

Also Known as KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114836

About SLAMF6

Cytogenetic location: 1q23.2-q23.3 Genomic coordinates (GRCh38): 1:160,485,036-160,523,255 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 29.2), spleen (RPKM 15.5) and 7 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

SLAMF6 Products (4)

mRNA	Protein	Name
NM_001184714.2	NP_001171643.1	SLAM family member 6 isoform 1 precursor
NM_001184715.2	NP_001171644.1	SLAM family member 6 isoform 3 precursor
NM_001184716.2	NP_001171645.1	SLAM family member 6 isoform 4 precursor
NM_052931.5	NP_443163.1	SLAM family member 6 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11489943	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	22184727	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	22184727	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	16920955	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16920955	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22184727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAMF6 Protein Structure

V-set

Ig_3

0
100
200
300
332 a.a.

Protein Preferred Names	Protein Names
SLAM family member 6	NK-T-B-antigen

SLAMF6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLAMF6	Q96DU3	SH2D1B	Homo sapiens	O14796	Anti Bait CoIP	16920955
Intra	SLAMF6	Q96DU3	SH2D1B	Homo sapiens	O14796	Anti Bait CoIP	23346089
Intra	SLAMF6	Q96DU3	SH2D1A	Homo sapiens	O60880	Pull Down	22912825
Intra	SLAMF6	Q96DU3	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	16920955
Intra	SLAMF6	Q96DU3	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	23346089
Intra	SLAMF6	Q96DU3	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	11489943
Intra	SLAMF6	Q96DU3	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	24688028
Intra	SLAMF6	Q96DU3	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71317	SLAMF6 Protein, Human (HEK293, His)	Q96DU3-1 (L28-K225)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72415	SLAMF6 Protein, Human (HEK293, His-Avi)	Q96DU3-1 (Q22-K225)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76645	SLAMF6 Protein, Human (HEK293)	Q96DU3-1 (Q22-M226)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76646	SLAMF6 Protein, Human (HEK293, Fc)	Q96DU3-1 (Q22-M226)	≥ 95%, as determined by reducing SDS-PAGE.

SLAMF6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81727	SLAMF6/CD352 Antibody (YA1472)	FC, ELISA	Human
HY-P82232	SLAMF6/CD352 Antibody (YA1977)	WB, ICC/IF, IP	Human
HY-P82232A	SLAMF6/CD352 Antibody (YA1977)(PBS only)	WB, ICC/IF, IP	Human
HY-P84727	SLAMF6/CD352 Antibody (YA4424)	IHC-P, FC, ELISA	Human
HY-P84727A	SLAMF6/CD352 Antibody (YA4424)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Selective Immunoglobulin Deficiency Disease
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Dysgammaglobulinemia
Ovarian Cystic Teratoma
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Mature Teratoma Of The Ovary
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12980	SLAMF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18877	Slamf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25368	Slamf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLAMF6	VGNC	VGNC:46207
Macaca mulatta	SLAMF6	VGNC	VGNC:77546
Bos taurus	SLAMF6	VGNC	VGNC:34654
Mus musculus	SLAMF6	MGD	MGI:1353620
Felis catus	SLAMF6	VGNC	VGNC:107939
Rattus norvegicus	SLAMF6	RGD	RGD:1561848
Others	SLAMF6	NCBI