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SH2D1B - SH2 domain containing 1B Gene

Also Known as EAT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117157

About SH2D1B

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,395,268-162,412,136 (from NCBI)

This gene has 2 transcripts (splice variants), 151 orthologues and 13 paralogues. Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 1.8) and 14 other tissues.

Summary

By binding phosphotyrosines through its free Src (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

SH2D1B Products (1)

mRNA	Protein	Name
NM_053282.5	NP_444512.2	SH2 domain-containing protein 1B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12928397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D1B Protein Structure

SH2

0
100
132 a.a.

Protein Preferred Names	Protein Names
SH2 domain-containing protein 1B	EAT-2

SH2D1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	SH2D1B	O14796	MET	Homo sapiens	P08581	FPS	24728074
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	SH2D1B	O14796	TNK2	Homo sapiens	Q07912-2	Validated Y2H	32296183
Intra	SH2D1B	O14796	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SH2D1B	O14796	SLAMF6	Homo sapiens	Q96DU3	Anti Bait CoIP	16920955
Intra	SH2D1B	O14796	CD244	Homo sapiens	Q9BZW8	Anti Bait CoIP	23346089
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SH2D1B	O14796	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	SH2D1B	O14796	OLIG1	Homo sapiens	Q8TAK6	Lumier	25814554
Intra	SH2D1B	O14796	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	SH2D1B	O14796	AR	Homo sapiens	P10275	FPS	24728074
Intra	SH2D1B	O14796	PLCG2	Homo sapiens	P16885	Pull Down	24642916
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Validated Y2H	32814053
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Y2H Array	32814053
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Y2H Pooling	32814053
Intra	SH2D1B	O14796	CD84	Homo sapiens	Q9UIB8	CoIP	12928397
Intra	SH2D1B	O14796	CD84	Homo sapiens	Q9UIB8	Pull Down	23322602
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Validated Y2H	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Y2H Array	32296183
Intra	SH2D1B	O14796	PLCG1	Homo sapiens	P19174	Pull Down	24642916
Intra	SH2D1B	O14796	PLCG1	Homo sapiens	P19174	SPR	24642916
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Y2H Pooling	32814053
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Validated Y2H	32814053
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Y2H Array	32814053
Intra	SH2D1B	O14796	q53hf2_human	Homo sapiens	Q53HF2	Y2H Array	25814554
Intra	SH2D1B	O14796	q53hf2_human	Homo sapiens	Q53HF2	Lumier	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Vertigo, Benign Recurrent	Benign Paroxysmal Positional Vertigo Bppv Vestibulopathy, Familial BRV Vertigo, Benign Paroxysmal Positional Benign Paroxysmal Positional Nystagmus Benign Recurrent Vertigo Familial Benign Recurrent Vertigo Familial Vestibulopathy Benign Paroxysmal Nystagmus Bppv - [Benign Positional Paroxysmal Vertigo]
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Cardiomyopathy, Familial Restrictive, 1	RCM1 Restrictive Cardiomyopathy 1 Rcm Familial Restrictive Cardiomyopathy 1 Cardiomyopathy, Familial Restrictive 1 Cardiomyopathy, Restrictive, Familial, Type 1 Rcm-1
Episodic Ataxia, Type 2	Episodic Ataxia Type 2 EA2 Apca Capa Cerebellopathy, Hereditary Paroxysmal Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive Episodic Ataxia With Nystagmus Ataxia, Episodic, With Nystagmus Episodic Ataxia, Nystagmus-Associated Ataxia, Familial Paroxysmal Acetazolamide-Responsive Episodic Ataxia Syndrome Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia Ataxia, Familial, Paroxysmal Nystagmus-Associated Episodic Ataxia Familial Paroxysmal Ataxia Episodic Ataxia 2 Ea-2 Episodic Ataxia Nystagmus-Associated Hereditary Paroxysmal Cerebellopathy Ataxia, Episodic, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12822	SH2D1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH2D1B	VGNC	VGNC:77349
Rattus norvegicus	SH2D1B	RGD	RGD:1563935
Canis familiaris	SH2D1B	VGNC	VGNC:53129
Bos taurus	SH2D1B	VGNC	VGNC:55680
Others	SH2D1B	NCBI