FOS - Fos proto-oncogene, AP-1 transcription factor subunit Gene

Also Known as p55; AP-1; C-FOS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2353

About FOS

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,278,828-75,282,230 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 802.2), gall bladder (RPKM 632.2) and 23 other tissues.

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

FOS Products (1)

mRNA	Protein	Name
NM_005252.4	NP_005243.1	protein c-Fos

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	30670568	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9732876	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10704222	GOA
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	9732876	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	30670568	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	10704222	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10508860	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23661758	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7816143	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9732876	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	10523647	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	9732876	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	17217916	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9732876	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	30670568	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10508860	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10523647	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10704222	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8628277	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	9732876	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9443941	GOA
part of protein-DNA complex	IMP IMP: Inferred from mutant phenotype	10704222	GOA
part of transcription factor AP-1 complex	IDA IDA: Inferred from direct assay	10508860	GOA
part of transcription factor AP-1 complex	IMP IMP: Inferred from mutant phenotype	26514923	GOA
part of transcription factor AP-1 complex	IPI IPI: Inferred from physical interaction	7816143	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOS Protein Structure

bZIP_1

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
protein c-Fos	FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)

FOS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOS	P01100	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Pooling	32814053
Intra	FOS	P01100	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32814053
Intra	FOS	P01100	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32814053
Intra	FOS	P01100	ASCL4	Homo sapiens	Q6XD76	Y2H Pooling	32814053
Intra	FOS	P01100	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32814053
Intra	FOS	P01100	ASCL4	Homo sapiens	Q6XD76	Y2H Array	32814053
Intra	FOS	P01100	JADE2	Homo sapiens	Q9NQC1-2	Y2H Array	32814053
Intra	FOS	P01100	JADE2	Homo sapiens	Q9NQC1-2	Validated Y2H	32814053
Intra	FOS	P01100	JADE2	Homo sapiens	Q9NQC1-2	Y2H Pooling	32814053
Intra	FOS	P01100	ULBP3	Homo sapiens	Q9BZM4	Y2H Array	32814053
Intra	FOS	P01100	ULBP3	Homo sapiens	Q9BZM4	Y2H Pooling	32814053
Intra	FOS	P01100	ULBP3	Homo sapiens	Q9BZM4	Validated Y2H	32814053
Intra	FOS	P01100	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32814053
Intra	FOS	P01100	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32814053
Intra	FOS	P01100	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Pooling	32814053
Intra	FOS	P01100	ZNG1A	Homo sapiens	Q9BRT8	Validated Y2H	32814053
Intra	FOS	P01100	ZNG1A	Homo sapiens	Q9BRT8	Y2H Array	32814053
Intra	FOS	P01100	ZNG1A	Homo sapiens	Q9BRT8	Y2H Pooling	32814053
Intra	FOS	P01100	STAT1	Homo sapiens	P42224	Anti Bait CoIP	12788789
Intra	FOS	P01100	STAT1	Homo sapiens	P42224	PLA	25241761
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	Display Tech	20195357
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	TAP	20195357
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	Anti Tag CoIP	28514442
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	TAP	25609649
Intra	FOS	P01100	ATF2	Homo sapiens	P15336	Validated Y2H	32296183
Intra	FOS	P01100	CEBPA	Homo sapiens	P49715	FRET	23661758
Intra	FOS	P01100	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32814053
Intra	FOS	P01100	GRB10	Homo sapiens	Q13322-4	Y2H Array	32814053
Intra	FOS	P01100	GRB10	Homo sapiens	Q13322-4	Y2H Pooling	32814053
Intra	FOS	P01100	COMMD10	Homo sapiens	Q9Y6G5	Validated Y2H	32814053
Intra	FOS	P01100	COMMD10	Homo sapiens	Q9Y6G5	Y2H Array	32814053
Intra	FOS	P01100	COMMD10	Homo sapiens	Q9Y6G5	Y2H Pooling	32814053
Cross	FOS	P01100	Maz	Mus musculus	P56671	Far-WB	19028685
Intra	FOS	P01100	PIK3CA	Homo sapiens	P42336	Y2H Array	32814053
Intra	FOS	P01100	PIK3CA	Homo sapiens	P42336	Y2H Pooling	32814053
Intra	FOS	P01100	PIK3CA	Homo sapiens	P42336	Validated Y2H	32814053
Intra	FOS	P01100	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
Intra	FOS	P01100	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
Intra	FOS	P01100	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
Intra	FOS	P01100	TNFAIP1	Homo sapiens	Q13829	Validated Y2H	32814053
Intra	FOS	P01100	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32814053
Intra	FOS	P01100	TNFAIP1	Homo sapiens	Q13829	Y2H Pooling	32814053
Intra	FOS	P01100	JUND	Homo sapiens	P17535	Anti Tag CoIP	28514442
Intra	FOS	P01100	JUND	Homo sapiens	P17535	Affinity Chrom	35140242
Intra	FOS	P01100	JUND	Homo sapiens	P17535	TAP	20195357
Intra	FOS	P01100	JUND	Homo sapiens	P17535	Anti Tag CoIP	26496610
Intra	FOS	P01100	JUND	Homo sapiens	P17535	Anti Bait CoIP	24029232
Intra	FOS	P01100	JUND	Homo sapiens	P17535	BioID	35140242
Intra	FOS	P01100	JUND	Homo sapiens	P17535	Anti Tag CoIP	33961781
Intra	FOS	P01100	JUND	Homo sapiens	P17535	TAP	25609649
Intra	FOS	P01100	ZNF133	Homo sapiens	P52736	TAP	20195357
Intra	FOS	P01100	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	FOS	P01100	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	FOS	P01100	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	FOS	P01100	ARHGDIB	Homo sapiens	P52566	Validated Y2H	32814053
Intra	FOS	P01100	ARHGDIB	Homo sapiens	P52566	Y2H Pooling	32814053
Intra	FOS	P01100	ARHGDIB	Homo sapiens	P52566	Y2H Array	32814053
Intra	FOS	P01100	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	FOS	P01100	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	FOS	P01100	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	FOS	P01100	PPP1R12A	Homo sapiens	O14974	TAP	25609649
Intra	FOS	P01100	PPP1R12A	Homo sapiens	O14974	Display Tech	20195357
Intra	FOS	P01100	MAFB	Homo sapiens	Q9Y5Q3	FRET	23661758
Intra	FOS	P01100	MAFB	Homo sapiens	Q9Y5Q3	Peptide Array	20102225
Intra	FOS	P01100	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	FOS	P01100	LPIN1	Homo sapiens	Q14693	Validated Y2H	32814053
Intra	FOS	P01100	LPIN1	Homo sapiens	Q14693	Y2H Array	32814053
Intra	FOS	P01100	LPIN1	Homo sapiens	Q14693	Y2H Pooling	32814053
Intra	FOS	P01100	ITGB3BP	Homo sapiens	Q13352	Y2H Pooling	32814053
Intra	FOS	P01100	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32814053
Intra	FOS	P01100	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32814053
Intra	FOS	P01100	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	FOS	P01100	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	FOS	P01100	RAB11B	Homo sapiens	Q15907	Y2H Array	32814053
Intra	FOS	P01100	RAB11B	Homo sapiens	Q15907	Validated Y2H	32814053
Intra	FOS	P01100	RAB11B	Homo sapiens	Q15907	Y2H Pooling	32814053
Intra	FOS	P01100	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	FOS	P01100	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	FOS	P01100	DDIT3	Homo sapiens	P35638	Lumier	37398436
Intra	FOS	P01100	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	FOS	P01100	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Y2H Array	20211142
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	FRET	23661758
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Anti Tag CoIP	26496610
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Anti Tag CoIP	28514442
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	TAP	25609649
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Anti Bait CoIP	24029232
Intra	FOS	P01100	JUNB	Homo sapiens	P17275	Affinity Chrom	35140242
Intra	FOS	P01100	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	FOS	P01100	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	FOS	P01100	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	FOS	P01100	TCL1A	Homo sapiens	P56279	Anti Bait CoIP	19064921
Intra	FOS	P01100	TCL1A	Homo sapiens	P56279	Anti Tag CoIP	19064921
Intra	FOS	P01100	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	FOS	P01100	ATF7	Homo sapiens	P17544	TAP	25609649
Intra	FOS	P01100	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	FOS	P01100	APP	Homo sapiens	P05067	Display Tech	20195357
Intra	FOS	P01100	APP	Homo sapiens	P05067	TAP	20195357
Intra	FOS	P01100	SCGB1A1	Homo sapiens	P11684	Y2H Array	32814053
Intra	FOS	P01100	SCGB1A1	Homo sapiens	P11684	Validated Y2H	32814053
Intra	FOS	P01100	SCGB1A1	Homo sapiens	P11684	Y2H Pooling	32814053
Intra	FOS	P01100	RPUSD4	Homo sapiens	Q96CM3	Y2H Array	32814053
Intra	FOS	P01100	RPUSD4	Homo sapiens	Q96CM3	Lumier	32814053
Intra	FOS	P01100	RPUSD4	Homo sapiens	Q96CM3	Y2H Pooling	32814053
Intra	FOS	P01100	RPUSD4	Homo sapiens	Q96CM3	Validated Y2H	32814053
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	FOS	P01100	JUN	Homo sapiens	P05412	BiFC	18172215
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Anti Tag CoIP	23602568
Intra	FOS	P01100	JUN	Homo sapiens	P05412	TAP	20195357
Intra	FOS	P01100	JUN	Homo sapiens	P05412	X-Ray Diffraction	7816143
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Anti Tag CoIP	28514442
Intra	FOS	P01100	JUN	Homo sapiens	P05412	TAP	25609649
Intra	FOS	P01100	JUN	Homo sapiens	P05412	FRET	23661758
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Anti Tag CoIP	26496610
Intra	FOS	P01100	JUN	Homo sapiens	P05412	ITC	21199371
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	FOS	P01100	JUN	Homo sapiens	P05412	BiFC	23602568
Intra	FOS	P01100	JUN	Homo sapiens	P05412	BioID	35140242
Intra	FOS	P01100	JUN	Homo sapiens	P05412	PLA	20511396
Intra	FOS	P01100	JUN	Homo sapiens	P05412	CD	21199371
Intra	FOS	P01100	JUN	Homo sapiens	P05412	Affinity Chrom	35140242
Intra	FOS	P01100	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	FOS	P01100	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	FOS	P01100	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

FOS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80081	c-Fos Antibody (YA506)	WB, IHC-P, ICC/IF	Human, Rat
HY-P80616	c-Fos Antibody	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P83898	c-Fos Antibody (YA3595)	WB, IHC-P, FC, ELISA	Human
HY-P83898A	c-Fos Antibody (YA3595)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85738	c-Fos Antibody (YA5430)	WB, ELISA, IF-Tissue	Human, Mouse, Rat
HY-P86346	c-Fos Antibody (YA6038)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86657	c-Fos Antibody (YA6349)	FC	Human

Related Diseases

Diseases	Alias
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Osteoblastoma
Myositis Ossificans	Myisitis Ossificans Ossification - Muscle
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Retrograde Amnesia	Amnesia, Retrograde
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Coffin-Lowry Syndrome	CLS Coffin Syndrome 1 Coffin Syndrome Intellectual Disability With Osteocartilaginous Abnormalities Dwarfism, Lean Spastic Type Lean Spastic Dwarfism Mental Retardation With Osteocartilaginous Abnormalities Coffin Lowry Syndrome
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Vestibular Nystagmus	Nystagmus Associated With Disorder Of The Vestibular System
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Opiate Dependence	Opioid Dependence Opioid Addiction Opiate Addiction Opioid Type Dependence Opioid-Related Disorders Opium Dependence Narcotic Dependence Intravenous Narcotism Narcotism Nos Oral Narcotism Nos
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Pain Agnosia	Analgesia
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Audiogenic Seizures	Audiogenic Seizure
Fasciitis
Morphine Dependence
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Histiocytoid Hemangioma	Angiolymphoid Hyperplasia With Eosinophilia Epithelioid Haemangioma Epithelioid Hemangioma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Motion Sickness	Airsickness Carsickness Seasickness Travel Sickness Riders' Vertigo
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Cyclotropia
Withdrawal Disorder	Withdrawal Syndrome Substance Withdrawal Syndrome
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Vitreoretinopathy, Neovascular Inflammatory	Proliferative Vitreoretinopathy Adniv Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy VRNI Pvr Neovascular Inflammatory Vitreoretinopathy Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant Retinitis Proliferans Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant Vitreoretinopathy Proliferative Vitreoretinopathy, Proliferative Proliferative Vitreo-Retinopathy
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Anterograde Amnesia	Amnesia, Anterograde
Developmental And Epileptic Encephalopathy 30	DEE30 Epileptic Encephalopathy, Early Infantile, 30 Eiee30 Developmental And Epileptic Encephalopathy, 30 Early Infantile Epileptic Encephalopathy 30 Encephalopathy, Epileptic, Early Infantile, Type 30
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Space Motion Sickness
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hemangioma	Hemangiomas
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Von Economo'S Disease	Encephalitis Lethargica Von Economo Encephalitis Von Economo Disease
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Drug Dependence
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Teeth Hard Tissue Disease
Specific Developmental Disorder
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 9 CMS9 Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Cocaine Abuse	Cocaine-Related Disorders
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Epilepsy, Idiopathic Generalized 4	EIG4 Epilepsy, Idiopathic Generalized, Susceptibility To 4 Idiopathic Generalized Epilepsy 4 Epilepsy, Idiopathic Generalized, Susceptibility To, 4 Epilepsy, Idiopathic Generalized Locus On Chromosome 10 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10
Disease Of Mental Health	Mental Health Mental Disorders
Bone Remodeling Disease
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Substance Dependence
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Bone Resorption Disease	Bone Resorption
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Goat Milk Allergy	Capra Hircus Milk Allergy
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Acute Salpingo-Oophoritis	Acute Salpingitis And Oophoritis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Developmental And Epileptic Encephalopathy 24	DEE24 Epileptic Encephalopathy, Early Infantile, 24 Eiee24 Developmental And Epileptic Encephalopathy, 24 Early Infantile Epileptic Encephalopathy 24 Encephalopathy, Epileptic, Early Infantile, Type 24
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Syndromic Intellectual Disability
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Myopathy	Muscular Diseases Myopathies
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Agonist	98.77%	Unkown
HY-B1052A	Lofexidine	Agonist	99.08%	Unkown
HY-B1052	Lofexidine hydrochloride	Agonist	99.72%	Unkown
HY-A0116A	Trandolaprilate hydrate	Inhibitor	97.30%	Unkown
HY-A0116	Trandolaprilate	Inhibitor	99.42%	Unkown
HY-B1052R	Lofexidine hydrochloride (Standard)	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-100426A	Osemozotan hydrochloride	Agonist	/	Phase 2
HY-113726	Nerisopam	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10408	Candidalysin	Activator	99.81%	Unkown
HY-N0231	Bavachalcone		99.90%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	99.0%	Unkown
HY-N6837	Fructo-oligosaccharide DP7/GF6		99.94%	Unkown
HY-P10927	BRP		99.62%	Unkown
HY-N5048	Galloylpaeoniflorin	Inhibitor	98.30%	Unkown
HY-N0805A	Alisol B		99.57%	Unkown
HY-165126	Schizophyllan		/	Unkown
HY-A0299	H-Gly-Pro-Hyp-OH	Inhibitor	99.48%	Unkown
HY-P10506	CMX-8933	Activator	99.77%	Unkown
HY-107621	U0124		98.0%	Unkown
HY-169021	JNK-1-IN-3	Inhibitor	98.44%	Unkown
HY-59201A	A-582941 dihydrochloride		99.78%	Unkown
HY-182757	Y1693	Inhibitor	99.91%	Unkown
HY-N6836	Fructo-oligosaccharide DP8/GF7		99.76%	Unkown
HY-124277	ADM 12	Antagonist	98.86%	Unkown
HY-P10927A	BRP TFA		/	Unkown
HY-B1052S	Lofexidine-d4 hydrochloride	Agonist	/	Unkown
HY-100839	(RS)-(Tetrazol-5-yl)glycine	Agonist	96.53%	Unkown
HY-106584	Mosapramine	Antagonist	98.58%	Unkown
HY-114753	Neboglamine	Modulator	/	Unkown
HY-168895	c-Fos-IN-1		97.24%	Unkown
HY-N6835	Fructo-oligosaccharide DP9/GF8		99.83%	Unkown
HY-P10405A	TAT-D1 peptide acetate	Inhibitor	/	Unkown
HY-RS05032	FOS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16815	Fos Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106153B	E-5842 citrate	Ligand	/	Unkown
HY-107614G	1-Oleoyl lysophosphatidic acid sodium (GMP)	Activator	/	Unkown
HY-113443	12(S)-HPETE	Activator	/	Unkown
HY-113756B	rel-Latanoprost acid	Agonist	/	Unkown
HY-116640	Amorphigenin	Inhibitor	/	Unkown
HY-120306	HHL-6	Inhibitor	/	Unkown
HY-12270S	T-5224-d8		/	Unkown
HY-131721	14,15-EET-SI	Activator	/	Unkown
HY-15026	ATB 429		/	Unkown
HY-168482	NF-κB/MAPK-IN-2	Inhibitor	/	Unkown
HY-168895A	(E,E)-c-Fos-IN-1		/	Unkown
HY-169451	Cannabidiolic acid methyl ester	Modulator	/	Unkown
HY-175007	RIPK1-IN-32	Inhibitor	/	Unkown
HY-176019	Methylcarbamyl PAF C-8		/	Unkown
HY-179216	KTT-1	Inhibitor	/	Unkown
HY-179684	PCC0105005		/	Unkown
HY-182504	NRA-0562		/	Unkown
HY-59201	A-582941		/	Unkown
HY-A0116S1	Trandolaprilate-d6		/	Unkown
HY-B1052S1	Lofexidine-d4	Agonist	/	Unkown
HY-E70684	CDK5/p25NCK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70685	CDK5/p35NCK Recombinant Human Active Protein Kinase		/	Unkown
HY-N11775	Eudebeiolide B		/	Unkown
HY-N1326	Santamarine		98.85%	Unkown
HY-N18209	4-Hydroxy-3-butylphthalide		/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-N6834	Fructo-oligosaccharide DP10/GF9		98.0%	Unkown
HY-P11617	CLP-d2	Inhibitor	/	Unkown
HY-174682	Human FOS mRNA		/	Unkown
HY-B1606	Chlorothymol		99.70%	Unkown
HY-N7008	Fructo-oligosaccharide DP11/GF10		/	Unkown
HY-N7009	Fructo-oligosaccharide DP12/GF11		98.0%	Unkown
HY-P10405	TAT-D1 peptide	Antagonist	/	Unkown
HY-RS23255	Fos Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOS	VGNC	VGNC:29073
Rattus norvegicus	FOS	RGD	RGD:2626
Macaca mulatta	FOS	VGNC	VGNC:84340
Felis catus	FOS	VGNC	VGNC:62329
Mus musculus	FOS	MGD	MGI:95574
Canis familiaris	FOS	VGNC	VGNC:40940
Others	FOS	NCBI