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COMMD10 - COMM domain containing 10 Gene

Also Known as PTD002

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51397

About COMMD10

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:116,085,025-116,293,287 (from NCBI)

This gene has 7 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 1.4), adrenal (RPKM 1.3) and 25 other tissues.

Summary

Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

COMMD10 Products (2)

mRNA	Protein	Name
NM_001308080.2	NP_001295009.1	COMM domain-containing protein 10 isoform b
NM_016144.4	NP_057228.1	COMM domain-containing protein 10 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD10 Protein Structure

COMM_domain

0
100
202 a.a.

Protein Preferred Names	Protein Names
COMM domain-containing protein 10

COMMD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COMMD10	Q9Y6G5	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	COMMD10	Q9Y6G5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	COMMD10	Q9Y6G5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	COMMD10	Q9Y6G5	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	COMMD10	Q9Y6G5	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	COMMD10	Q9Y6G5	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	COMMD10	Q9Y6G5	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	28514442
Intra	COMMD10	Q9Y6G5	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD10	Q9Y6G5	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
Intra	COMMD10	Q9Y6G5	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	37172566
Intra	COMMD10	Q9Y6G5	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	33961781
Intra	COMMD10	Q9Y6G5	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	28514442
Intra	COMMD10	Q9Y6G5	COMMD5	Homo sapiens	Q9GZQ3	TAP	23563313
Intra	COMMD10	Q9Y6G5	GATM	Homo sapiens	P50440	Validated Y2H	32814053
Intra	COMMD10	Q9Y6G5	GATM	Homo sapiens	P50440	Y2H Array	32814053
Intra	COMMD10	Q9Y6G5	GATM	Homo sapiens	P50440	Y2H Pooling	32814053
Intra	COMMD10	Q9Y6G5	CCDC22	Homo sapiens	O60826	Pull Down	23563313
Intra	COMMD10	Q9Y6G5	CCDC22	Homo sapiens	O60826	TAP	23563313
Intra	COMMD10	Q9Y6G5	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	33961781
Intra	COMMD10	Q9Y6G5	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	28514442
Intra	COMMD10	Q9Y6G5	CCDC22	Homo sapiens	O60826	Anti Bait CoIP	23563313

Cross: Cross-species interaction Intra: Intraspecies interaction

COMMD10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86819	COMMD10 Antibody (YA6512)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 20	NPHS20 Nephrotic Syndrome Type 20 Nephrotic Syndrome 20

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19587	Ditercalinium chloride	Inhibitor	96.12%	Unkown
HY-RS03010	COMMD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	COMMD10	VGNC	VGNC:39492
Macaca mulatta	COMMD10	VGNC	VGNC:71374
Bos taurus	COMMD10	VGNC	VGNC:27582
Rattus norvegicus	COMMD10	RGD	RGD:1303015
Felis catus	COMMD10	VGNC	VGNC:61075
Mus musculus	COMMD10	MGD	MGI:1916706
Others	COMMD10	NCBI