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UQCRC1 - ubiquinol-cytochrome c reductase core protein 1 Gene

Also Known as QCR1; PKNPY; UQCR1; D3S3191

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7384

About UQCRC1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,599,002-48,609,646 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 170.6), kidney (RPKM 96.0) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in Oxidative Phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

UQCRC1 Products (1)

mRNA	Protein	Name
NM_003365.3	NP_003356.2	cytochrome b-c1 complex subunit 1, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32161263	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRC1 Protein Structure

Peptidase_M16

Peptidase_M16_C

0
100
200
300
400
480 a.a.

Protein Preferred Names	Protein Names
cytochrome b-c1 complex subunit 1, mitochondrial	complex III subunit 1

UQCRC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Validated Y2H	32814053
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Y2H Array	32814053
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Y2H Pooling	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Validated Y2H	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Y2H Pooling	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Y2H Array	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Y2H Array	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Validated Y2H	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Y2H Pooling	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Y2H Pooling	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Validated Y2H	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Y2H Array	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Y2H Pooling	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Validated Y2H	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Y2H Array	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

UQCRC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84257	UQCRC1 Antibody (YA3954)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84257A	UQCRC1 Antibody (YA3954)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Parkinsonism With Polyneuropathy	PKNPY
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Polyneuropathy	Polyneuropathies
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Mitochondrial Complex V Deficiency, Nuclear Type 3	Mitochondrial Complex Iii Deficiency Nuclear Type 5 MC5DN3 Mitochondrial Complex Iii Deficiency, Nuclear Type 5 Mitochondrial Complex V Deficiency Nuclear Type 3 MC3DN5 Mitochondrial Complex V Deficiency, Atp5e Type Mitochondrial Complex Iii Deficiency, Nuclear 5 Mitochondrial Complex V Deficiency, Nuclear Type 3 Mitochondrial Complex V Deficiency Atp5e Type Mitochondrial Complex V Deficiency Type 3 Mitochondrial Complex V Deficiency, Nuclear, Type 3
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Leigh Syndrome, French Canadian Type Mitochondrial Complex V Deficiency Nuclear Type 4 Cytochrome C Oxidase Deficiency, French Canadian Type Lsfc Cox Deficiency, French Canadian Type MC5DN4 MC4DN5 Cox Deficiency, Saguenay-Lac-Saint-Jean Type Leigh Syndrome, Saguenay-Lac-Saint-Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 French Canadian Leigh Disease Leigh Syndrome, French-Canadian Type Leigh Syndrome , French Canadian Type Mitochondrial Complex V Deficiency, Atp5a1 Type French Canadian Type Cox Deficiency French Canadian Type Cytochrome C Oxidase Deficiency French Canadian Type Leigh Syndrome Saguenay Lac Saint Jean Type Cox Deficiency Saguenay Lac Saint Jean Type Leigh Syndrome Cox Deficiency, Saguenay Lac Saint Jean Type Leigh Syndrome, Saguenay Lac Saint Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 Mitochondrial Complex V Deficiency Atp5a1 Type Mitochondrial Complex V Deficiency Type 4 Mitochondrial Complex V Deficiency, Nuclear, Type 4
Mitochondrial Complex Iii Deficiency	Complex 3 Mitochondrial Respiratory Chain Deficiency Isolated Coq-Cytochrome C Reductase Deficiency Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15499	UQCRC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UQCRC1	RGD	RGD:1303314
Macaca mulatta	UQCRC1	VGNC	VGNC:78729
Mus musculus	UQCRC1	MGD	MGI:107876
Felis catus	UQCRC1	VGNC	VGNC:66848
Bos taurus	UQCRC1	VGNC	VGNC:36695
Canis familiaris	UQCRC1	VGNC	VGNC:48163
Others	UQCRC1	NCBI