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Sciadopitysin 

Cat. No.: HY-N2119 Purity: >99.0%
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Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1.

For research use only. We do not sell to patients.

Sciadopitysin Chemical Structure

Sciadopitysin Chemical Structure

CAS No. : 521-34-6

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5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 202 In-stock
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20 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].

IC50 & Target

NF-κB

 

In Vitro

Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2].

In Vivo

Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2].

Molecular Weight

580.54

Formula

C₃₃H₂₄O₁₀

CAS No.

521-34-6

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(OC)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

SciadopitysinNF-κBNuclear factor-κBNuclear factor-kappaBBiflavonoidsginkgobilobaosteoclastogenesisbonelossInhibitorinhibitorinhibit

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Sciadopitysin
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