Eudebeiolide B
Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.
For research use only. We do not sell to patients.
- CAS No.: 1934299-51-0
- Formula: C15H18O4
- Molecular Weight:262.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Akt |
NF-κB |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
27.8 μM
Compound: 10
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Down regulation of PCSK9 mRNA expression in human HepG2 cells incubated for 24 hrs by SYBR green dye-based qRT-PCR analysis
Down regulation of PCSK9 mRNA expression in human HepG2 cells incubated for 24 hrs by SYBR green dye-based qRT-PCR analysis
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[PMID: 33567826] |
| RAW264.7 | IC50 |
68.9 μM
Compound: 18
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay
Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay
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[PMID: 28960981] |
Eudebeiolide B (1-30 μΜ, 1 hour) suppresses RANKL-induced osteoclast differentiation and function in mouse bone marrow macrophages (BMMs)[1].
Eudebeiolide B (1-30 μΜ, 1 hour) inhibits the expression of osteoclastogenesis-related marker genes and RANKL-mediated cellular signaling [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Bone marrow macrophages (BMMs)
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Concentration:1-30 μΜ
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Incubation Time:1 hours
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Result:Inhibited RANKL-induced osteoclast differentiation of BMMs, bone resorption, and promotes osteoblast differentiation.
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Cell Line:Bone marrow macrophages (BMMs), MC3T3-E1 cells
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Concentration:10 μΜ
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Incubation Time:1 hours
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Result:Downregulated the expression of NFATc1 and c-fos, transcription factors induced by RANKL.
Attenuated the RANKL-induced expression of osteoclastogenesis-related genes, including Ctsk, MMP9 and DC-STAMP.
Induced the expression of alkaline phosphatase (ALP) and calcium accumulation during MC3T3-E1 osteoblast differentiation.
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Cell Line:Bone marrow macrophages (BMMs)
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Concentration:10 μΜ
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Incubation Time:1 hours
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Result:Inhibited the phosphorylation of Akt and NF-κB p65.
Downregulated the expression of CREB, Btk and phospholipase PLCγ2 in RANKL-induced calcium signaling.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized (OVX) mouse model[1]
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Dosage:5 or 10 mg/kg
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Administration:After 6 weeks of ovarian resection, intragastric injection (i.g.) once daily for 6 weeks.
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Result:Prevented bone mineral density (BMD) loss and bone mineral content (BMC) loss compared to the OVX mice.
Chemical Information
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CAS No. 1934299-51-0
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Molecular Weight 262.30
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Formula C15H18O4
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SMILES
O[C@]12C(C[C@@]3([H])[C@](C1)(C=CC([C@@H]3C)=O)C)=C(C(O2)=O)C
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Synonyms
Plebeiolide D
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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