2. NF-κB PI3K/Akt/mTOR Immunology/Inflammation Metabolic Enzyme/Protease
  3. NF-κB Akt Nuclear Factor of activated T Cells (NFAT) Phosphatase
  4. Eudebeiolide B

Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.

For research use only. We do not sell to patients.

Eudebeiolide B Chemical Structure

Eudebeiolide B Chemical Structure

CAS No. : 1934299-51-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Eudebeiolide B Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms

View All Akt Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research[1].

IC50 & Target[1]

Akt

 

NF-κB

 

In Vitro

Eudebeiolide B (1-30 μΜ, 1 hour) suppresses RANKL-induced osteoclast differentiation and function in mouse bone marrow macrophages (BMMs)[1].
Eudebeiolide B (1-30 μΜ, 1 hour) inhibits the expression of osteoclastogenesis-related marker genes and RANKL-mediated cellular signaling [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eudebeiolide B Related Antibodies

Cell Differentiation Assay[1]

Cell Line: Bone marrow macrophages (BMMs)
Concentration: 1-30 μΜ
Incubation Time: 1 hours
Result: Inhibited RANKL-induced osteoclast differentiation of BMMs, bone resorption, and promotes osteoblast differentiation.

RT-PCR[1]

Cell Line: Bone marrow macrophages (BMMs), MC3T3-E1 cells
Concentration: 10 μΜ
Incubation Time: 1 hours
Result: Downregulated the expression of NFATc1 and c-fos, transcription factors induced by RANKL.
Attenuated the RANKL-induced expression of osteoclastogenesis-related genes, including Ctsk, MMP9 and DC-STAMP.
Induced the expression of alkaline phosphatase (ALP) and calcium accumulation during MC3T3-E1 osteoblast differentiation.

Western Blot Analysis[1]

Cell Line: Bone marrow macrophages (BMMs)
Concentration: 10 μΜ
Incubation Time: 1 hours
Result: Inhibited the phosphorylation of Akt and NF-κB p65.
Downregulated the expression of CREB, Btk and phospholipase PLCγ2 in RANKL-induced calcium signaling.
In Vivo

Eudebeiolide B (5 or 10 mg/kg, i.g., once daily for 6 weeks) prevents OVX-induced bone loss in an ovariectomized (OVX) mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized (OVX) mouse model[1]
Dosage: 5 or 10 mg/kg
Administration: After 6 weeks of ovarian resection, intragastric injection (i.g.) once daily for 6 weeks.
Result: Prevented bone mineral density (BMD) loss and bone mineral content (BMC) loss compared to the OVX mice.
Molecular Weight

262.30

Formula

C15H18O4
CAS No.
SMILES

O[C@]12C(C[C@@]3([H])[C@](C1)(C=CC([C@@H]3C)=O)C)=C(C(O2)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Eudebeiolide B Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eudebeiolide B1934299-51-0Plebeiolide DNF-κBAktNuclear Factor of activated T Cells (NFAT)PhosphataseNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BMC3T3-E1Bone marrow macrophagesBMMsOsteoclastogenesis InhibitorSalvia plebeiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Eudebeiolide B
Cat. No.:
HY-N11775
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.