1. GPCR/G Protein
  2. CRFR
  3. Antisauvagine-30 TFA

Antisauvagine-30 TFA (Synonyms: aSvg-30 TFA)

Cat. No.: HY-P1107A
Handling Instructions

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

For research use only. We do not sell to patients.

Antisauvagine-30 TFA Chemical Structure

Antisauvagine-30 TFA Chemical Structure

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Description

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively[1][2][3][4].

IC50 & Target

Kd: 1.4 nM (mCRFR2β), 150 nM (CRFR1).

In Vitro

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice[1][2].

In Vivo

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2].
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect[3].

Animal Model: Nine-week-old male BALB/c mice[2].
Dosage: 400 ng/0.5 μl per mouse.
Administration: Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result: Prevented the stress-induced enhancement of fear conditioning.
Molecular Weight

3764.28

Formula

C₁₆₃H₂₇₅N₄₈F₃O₄₉S

Sequence

{D-Phe}{His}{Leu}{Leu}{Arg}{Lys}{Met}{Ile}{Glu}{Ile}{Glu}{Lys}{Gln}{Glu}{Lys}{Glu}{Lys}{Gln}{Gln}{Ala}{Ala}{Asn}{Asn}{Arg}{Leu}{Leu}{Leu}{Asp}{Thr}{Ile}-NH2

Sequence Shortening

(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2

SMILES

OC(C(F)(F)F)=O.[(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Antisauvagine-30aSvg-30Antisauvagine30Antisauvagine 30aSvg30aSvg 30CRFRCorticotropin-releasing Factor ReceptorstressfearmemoryanxiogenicInhibitorinhibitorinhibit

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Antisauvagine-30 TFA
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