1. GPCR/G Protein
  2. CRFR
  3. Antisauvagine-30 TFA

Antisauvagine-30 TFA  (Synonyms: aSvg-30 TFA)

Cat. No.: HY-P1107A Purity: 98.10%
COA Handling Instructions

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

For research use only. We do not sell to patients.

Antisauvagine-30 TFA Chemical Structure

Antisauvagine-30 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 320 In-stock
10 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Antisauvagine-30 TFA:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively[1][2][3][4].

IC50 & Target

Kd: 1.4 nM (mCRFR2β), 150 nM (CRFR1).

In Vitro

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2].
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nine-week-old male BALB/c mice[2].
Dosage: 400 ng/0.5 μl per mouse.
Administration: Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result: Prevented the stress-induced enhancement of fear conditioning.
Molecular Weight

3764.28

Formula

C163H275N48F3O49S

Appearance

Solid

Color

White to off-white

Sequence Shortening

{D-Phe}-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2

SMILES

[(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2 (TFA salt)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (6.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2657 mL 1.3283 mL 2.6566 mL
5 mM 0.0531 mL 0.2657 mL 0.5313 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2657 mL 1.3283 mL 2.6566 mL 6.6414 mL
5 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3283 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Antisauvagine-30 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antisauvagine-30 TFA
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