1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. (RS)-(Tetrazol-5-yl)glycine

(RS)-(Tetrazol-5-yl)glycine (Synonyms: D,L-(tetrazol-5-yl)glycine; LY 285265)

Cat. No.: HY-100839
Handling Instructions

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice.

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(RS)-(Tetrazol-5-yl)glycine Chemical Structure

(RS)-(Tetrazol-5-yl)glycine Chemical Structure

CAS No. : 138199-51-6

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Description

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3].

IC50 & Target

EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)[1]

In Vitro

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands[1].
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM)[1].

In Vivo

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice[3].
(RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.) [1].

Animal Model: C57BL/6 mice[3]
Dosage: 1.25, 1.5 mg/kg
Administration: IP
Result: Induced seizure responses and Fos.
Molecular Weight

143.10

Formula

C₃H₅N₅O₂

CAS No.

138199-51-6

SMILES

O=C(O)C(N)C1=NNN=N1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(RS)-(Tetrazol-5-yl)glycineD,L-(tetrazol-5-yl)glycineLY 285265LY285265LY-285265iGluRIonotropic glutamate receptorsN-methyl-D-aspartateNMDAGluN1GluN2DGluN2AseizureFosInhibitorinhibitorinhibit

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(RS)-(Tetrazol-5-yl)glycine
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