(RS)-(Tetrazol-5-yl)glycine  (Synonyms: D,L-(tetrazol-5-yl)glycine; LY 285265)

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist^[1]. (RS)-(Tetrazol-5-yl)glycine has EC₅₀s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively^[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice^[3].

EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)^[1]

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [³H]CGS19755 (IC₅₀=98 nM) and [³H]glutamate (IC₅₀=36 nM) as ligands^[1].
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [³H]kainate, or [³H]glycine (IC₅₀s>30 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(RS)-(Tetrazol-5-yl)glycine can be used in animal modeling to construct epilepsy models.

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice^[3].
(RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED₅₀=0.071 mg/kg; i.p.) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

143.10

C₃H₅N₅O₂

138199-51-6

O=C(O)C(N)C1=NNN=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.