1. Metabolic Enzyme/Protease
    Epigenetics
    Cell Cycle/DNA Damage
    Anti-infection
    Apoptosis
  2. Phosphatase
    Sirtuin
    Reverse Transcriptase
    Topoisomerase
    Parasite
    Apoptosis
  3. Suramin

Suramin 

Cat. No.: HY-B0879
Handling Instructions

Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

For research use only. We do not sell to patients.

Suramin Chemical Structure

Suramin Chemical Structure

CAS No. : 145-63-1

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Top Publications Citing Use of Products

    Suramin purchased from MCE. Usage Cited in: J Biol Chem. 2020 Jul 24;295(30):10281-10292.

    Suramin inhibits IP5K function in vivo. Immunoprecipitation of myc-CSN2 from myc-CSN2-HEK293 stable cell after IP5K knockdown, with or without Suramin or NF449 treatment.

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    Description

    Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[5][6][7].

    IC50 & Target[2]

    SIRT1

    297 nM (IC50)

    SIRT2

    1.15 μM (IC50)

    SIRT5

    22 μM (IC50)

    In Vitro

    Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[6].
    Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells[6].
    Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[7].
    The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[6]

    Cell Line: HO-8910 PM ovarian and Hela cervical cancer cells
    Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL
    Incubation Time: For 24, 48, 72 and 96 hours
    Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner.

    Apoptosis Analysis[6]

    Cell Line: HeLa cells
    Concentration: 300 μg/mL
    Incubation Time: For 48 hours
    Result: Induced cells apoptosis.

    Western Blot Analysis[7]

    Cell Line: PA-SMCs cells
    Concentration: 1 mg/mL
    Incubation Time: For 1 hours
    Result: Significantly suppressed the phosphorylated ERK1/2.
    In Vivo

    Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[7].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Wistar rats (200-225 g)[7]
    Dosage: 10 mg/kg
    Administration: IV; twice weekly for 3 weeks
    Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
    Clinical Trial
    Molecular Weight

    1297.28

    Formula

    C₅₁H₄₀N₆O₂₃S₆

    CAS No.

    145-63-1

    SMILES

    O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O)=O)C4=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O)=O)C8=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C78)=O)=CC=C6C)=O)=CC=C5

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    SuraminPhosphataseSirtuinReverse TranscriptaseTopoisomeraseParasiteApoptosisprotein-tyrosinephosphatasesPTPasesDNAtopoisomeraseIIantitrypanosomalanti-neoplasticanti-angiogenicIP5KantiparasiticInhibitorinhibitorinhibit

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