1. GPCR/G Protein
    Immunology/Inflammation
  2. P2Y Receptor
    Interleukin Related
  3. Suramin sodium salt

Suramin sodium salt (Synonyms: Suramin hexasodium salt)

Cat. No.: HY-B0879A Purity: 99.93%
Handling Instructions

Suramin sodium salt (Suramin hexasodium salt), a polysulfonated naphthylurea, is a potent competitive DNA topoisomerase II inhibitor with an IC50 of 5 μM. Suramin sodium salt inhibits IL-4 with an IC50 of 55-70 μM. Suramin sodium salt has antiproliferative, anticancer, and anti-HIV activities and prevents binding of a variety of growth factors to their respective receptors.

For research use only. We do not sell to patients.

Suramin sodium salt Chemical Structure

Suramin sodium salt Chemical Structure

CAS No. : 129-46-4

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Based on 1 publication(s) in Google Scholar

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Description

Suramin sodium salt (Suramin hexasodium salt), a polysulfonated naphthylurea, is a potent competitive DNA topoisomerase II inhibitor with an IC50 of 5 μM[1][2][3][4]. Suramin sodium salt inhibits IL-4 with an IC50 of 55-70 μM. Suramin sodium salt has antiproliferative, anticancer, and anti-HIV activities and prevents binding of a variety of growth factors to their respective receptors[5].

IC50 & Target

IC50: 5 μM (DNA topoisomerase II)[3]; 55-70 μM (IL-4) [5]

In Vitro

Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 µM) than is DNA polymerase δ (IC50=36 µM), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 µM)[1]. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments[2]. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM[3].

In Vivo

Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen[4].

Clinical Trial
Molecular Weight

1429.17

Formula

C₅₁H₃₄N₆Na₆O₂₃S₆

CAS No.

129-46-4

SMILES

O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)([O-])=O)C4=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)([O-])=O)C8=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C78)=O)=CC=C6C)=O)=CC=C5.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (139.94 mM)

DMSO : 5.6 mg/mL (3.92 mM; Need warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6997 mL 3.4985 mL 6.9971 mL
5 mM 0.1399 mL 0.6997 mL 1.3994 mL
10 mM 0.0700 mL 0.3499 mL 0.6997 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[2]

The ATPase assay is performed in a 10 μL reaction mixture containing 20 mM Tris-HCl (pH 7.5), 1 mM DTT, 8 mM MgCl2, 5 μM M13 circular ssDNA, 2.5 μM RecA from the specified bacterial species and increasing concentrations of suramin. The reaction is initiated by the addition of 2 mM [α-32P]ATP, incubated for 30 min at 37°C and stopped by the addition of 25 mM EDTA[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[4]

Rats: To assess the potential preventive and curative effects of suramin, rats are randomly divided into four groups after MCT injection. In the preventive strategy, the treatment is started on the first day, and one group receives 10 mg/kg suramin intravenously twice weekly for 3 weeks, while a second group receives only the vehicle at the same time points. To assess the potential curative effects of suramin, rats are given MCT and are left untreated for 21 days before being randomly divided into two groups that are subsequently treated with either suramin or vehicle from day 21 to day 42 inclusive. The effect of suramin on survival is evaluated from the day 21 of MCT injection to day 42 corresponding to the treatment period[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.93%

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Keywords:

SuraminSuramin hexasodiumP2Y ReceptorInterleukin RelatedILInhibitorinhibitorinhibit

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Suramin sodium salt
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