1. Metabolic Enzyme/Protease
    Epigenetics
    Cell Cycle/DNA Damage
    Anti-infection
    Apoptosis
  2. Phosphatase
    Sirtuin
    Reverse Transcriptase
    Topoisomerase
    Parasite
    Apoptosis
  3. Suramin sodium salt

Suramin sodium salt (Synonyms: Suramin hexasodium salt)

Cat. No.: HY-B0879A Purity: 99.93%
Handling Instructions

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

For research use only. We do not sell to patients.

Suramin sodium salt Chemical Structure

Suramin sodium salt Chemical Structure

CAS No. : 129-46-4

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Suramin sodium salt:

Top Publications Citing Use of Products

    Suramin sodium salt purchased from MCE. Usage Cited in: J Biol Chem. 2020 Jul 24;295(30):10281-10292.

    Suramin inhibits IP5K function in vivo. Immunoprecipitation of myc-CSN2 from myc-CSN2-HEK293 stable cell after IP5K knockdown, with or without Suramin or NF449 treatment.

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    • Biological Activity

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    • References

    • Customer Review

    Description

    Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[5][6][7].

    IC50 & Target

    SIRT1

    297 nM (IC50)

    SIRT2

    1.15 μM (IC50)

    SIRT5

    22 μM (IC50)

    In Vitro

    Suramin sodium salt (Suramin hexasodium salt; 50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[6].
    Suramin sodium salt (300 μg/mL; for 48 hours) induces cells apoptosis and down-regulates mRNA expression in HeLa cells[6].
    Suramin sodium salt (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[7].
    The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[6].

    Cell Proliferation Assay[6]

    Cell Line: HO-8910 PM ovarian and Hela cervical cancer cells
    Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL
    Incubation Time: For 24, 48, 72 and 96 hours
    Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner.

    Apoptosis Analysis[6]

    Cell Line: HeLa cells
    Concentration: 300 μg/mL
    Incubation Time: For 48 hours
    Result: Induced cells apoptosis.

    Western Blot Analysis[7]

    Cell Line: PA-SMCs cells
    Concentration: 1 mg/mL
    Incubation Time: For 1 hour
    Result: Significantly suppressed the phosphorylated ERK1/2.
    In Vivo

    Suramin sodium salt (Suramin hexasodium salt; 10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[7].

    Animal Model: Adult male Wistar rats (200-225 g)[7]
    Dosage: 10 mg/kg
    Administration: IV; twice weekly for 3 weeks
    Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
    Clinical Trial
    Molecular Weight

    1429.17

    Formula

    C₅₁H₃₄N₆Na₆O₂₃S₆

    CAS No.

    129-46-4

    SMILES

    O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6C)=O)=CC=C5

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 200 mg/mL (139.94 mM)

    DMSO : 5.6 mg/mL (3.92 mM; Need warming)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6997 mL 3.4985 mL 6.9971 mL
    5 mM 0.1399 mL 0.6997 mL 1.3994 mL
    10 mM 0.0700 mL 0.3499 mL 0.6997 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.93%

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    Keywords:

    SuraminSuramin hexasodiumPhosphataseSirtuinReverse TranscriptaseTopoisomeraseParasiteApoptosisprotein-tyrosinephosphatasesPTPasesDNAtopoisomeraseIIantitrypanosomalanti-neoplasticanti-angiogenicIP5KantiparasiticInhibitorinhibitorinhibit

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    Suramin sodium salt
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