138199-51-6
138199-51-6
Chemical Structure
(RS)-(Tetrazol-5-yl)glycine
Synonym(s): D,L-(tetrazol-5-yl)glycine; LY 285265
- CAS No.: 138199-51-6
- Formula:C3H5N5O2
- Molecular Weight:143.10
IUPAC Name: 2-amino-2-(2H-tetrazol-5-yl)acetic acid
InChIKey: UKBRUIZWQZHXFL-UHFFFAOYSA-N
SMILES: O=C(O)C(N)C1=NNN=N1
Biological Activity: (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3].
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(RS)-(Tetrazol-5-yl)glycine | 96.53% | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice. | ||||||||||||||||||||
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References
- [1]. Schoepp DD, et al. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol. 1991 Oct 15;203(2):237-43. [Content Brief]
- [2]. Vance KM, et al. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun. 2011;2:294. [Content Brief]
- [3]. Duncan GE, et al. Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a geneticmodel of NMDA receptor hypofunction. Brain Res. 2008 Jul 24;1221:41-8. [Content Brief]
Keywords
