2. Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway Apoptosis
  3. AP-1 ERK Apoptosis
  4. c-Fos-IN-1

c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth.

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c-Fos-IN-1

c-Fos-IN-1 Chemical Structure

CAS No. : 3125025-31-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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c-Fos-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All AP-1 Isoform Specific Products:

View All Isoforms
c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

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Description

c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1].

IC50 & Target[1]

c-Fos

 

c-Jun

 

Molecular Weight

433.58

Formula

C28H35NO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(/C=C/[C@@H]1C(CCC2[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=C/3)NC3=C/C4=CC=C(C)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (230.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3064 mL 11.5319 mL 23.0638 mL
5 mM 0.4613 mL 2.3064 mL 4.6128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3064 mL 11.5319 mL 23.0638 mL 57.6595 mL
5 mM 0.4613 mL 2.3064 mL 4.6128 mL 11.5319 mL
10 mM 0.2306 mL 1.1532 mL 2.3064 mL 5.7659 mL
15 mM 0.1538 mL 0.7688 mL 1.5376 mL 3.8440 mL
20 mM 0.1153 mL 0.5766 mL 1.1532 mL 2.8830 mL
25 mM 0.0923 mL 0.4613 mL 0.9226 mL 2.3064 mL
30 mM 0.0769 mL 0.3844 mL 0.7688 mL 1.9220 mL
40 mM 0.0577 mL 0.2883 mL 0.5766 mL 1.4415 mL
50 mM 0.0461 mL 0.2306 mL 0.4613 mL 1.1532 mL
60 mM 0.0384 mL 0.1922 mL 0.3844 mL 0.9610 mL
80 mM 0.0288 mL 0.1441 mL 0.2883 mL 0.7207 mL
100 mM 0.0231 mL 0.1153 mL 0.2306 mL 0.5766 mL
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c-Fos-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Fos-IN-13125025-31-9AP-1ERKApoptosisActivator Protein 1Extracellular signal regulated kinasesMGC-803gastric canceranticancercell cycletumor growthMGC-803 xenograftInhibitorinhibitorinhibit

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