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  3. Drug Isomer
  4. (E,E)-c-Fos-IN-1

(E,E)-c-Fos-IN-1 is the active stereoisomer of c-Fos-IN-1 (HY-168895) in which both double bonds are in the trans configuration. c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth.

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(E,E)-c-Fos-IN-1

(E,E)-c-Fos-IN-1 Chemical Structure

CAS No. : 3125025-29-5

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Description

(E,E)-c-Fos-IN-1 is the active stereoisomer of c-Fos-IN-1 (HY-168895) in which both double bonds are in the trans configuration. c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1].

Molecular Weight

433.58

Formula

C28H35NO3
CAS No.
SMILES

O=C(C(/C=C/[C@@H]1C(CCC2[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=C/3)NC3=C\C4=CC=C(C)C=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (57.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3064 mL 11.5319 mL 23.0638 mL
5 mM 0.4613 mL 2.3064 mL 4.6128 mL
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3064 mL 11.5319 mL 23.0638 mL 57.6595 mL
5 mM 0.4613 mL 2.3064 mL 4.6128 mL 11.5319 mL
10 mM 0.2306 mL 1.1532 mL 2.3064 mL 5.7659 mL
15 mM 0.1538 mL 0.7688 mL 1.5376 mL 3.8440 mL
20 mM 0.1153 mL 0.5766 mL 1.1532 mL 2.8830 mL
25 mM 0.0923 mL 0.4613 mL 0.9226 mL 2.3064 mL
30 mM 0.0769 mL 0.3844 mL 0.7688 mL 1.9220 mL
40 mM 0.0577 mL 0.2883 mL 0.5766 mL 1.4415 mL
50 mM 0.0461 mL 0.2306 mL 0.4613 mL 1.1532 mL
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(E,E)-c-Fos-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E,E)-c-Fos-IN-13125025-29-5Drug IsomerInhibitorinhibitorinhibit

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