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ITGB3BP - integrin subunit beta 3 binding protein Gene

Also Known as CENPR; NRIF3; TAP20; CENP-R; HSU37139

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23421

About ITGB3BP

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:63,440,770-63,529,187 (from NCBI)

This gene has 14 transcripts (splice variants) and 120 orthologues. Ubiquitous expression in testis (RPKM 5.3), adrenal (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces Apoptosis in breast Cancer cells through a Caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

ITGB3BP Products (5)

mRNA	Protein	Name
NM_001206739.2	NP_001193668.1	centromere protein R isoform 1
NM_001347145.2	NP_001334074.1	centromere protein R isoform 3
NM_001347147.2	NP_001334076.1	centromere protein R isoform 4
NM_001347148.2	NP_001334077.1	centromere protein R isoform 5
NM_014288.5	NP_055103.3	centromere protein R isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB3BP Protein Structure

CENP-R

0
100
177 a.a.

Protein Preferred Names	Protein Names
centromere protein R	beta 3 endonexin

ITGB3BP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGB3BP	Q13352	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	ITGB3BP	Q13352	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	ITGB3BP	Q13352	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	31515488
Intra	ITGB3BP	Q13352	NRDE2	Homo sapiens	Q9H7Z3	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	KIAA0930	Homo sapiens	Q6ICG6-3	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	ITGB3BP	Q13352	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	ITGB3BP	Q13352	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ITGB3BP	Q13352	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ITGB3BP	Q13352	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	ITGB3BP	Q13352	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	ITGB3BP	Q13352	CENPU	Homo sapiens	Q71F23	Anti Tag CoIP	33961781
Intra	ITGB3BP	Q13352	CENPU	Homo sapiens	Q71F23	Anti Tag CoIP	26496610
Intra	ITGB3BP	Q13352	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	ITGB3BP	Q13352	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ITGB3BP	Q13352	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ITGB3BP	Q13352	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ITGB3BP	Q13352	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	ITGB3BP	Q13352	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	ITGB3BP	Q13352	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	ITGB3BP	Q13352	GRB2	Homo sapiens	P62993	Y2H Array	32814053
Intra	ITGB3BP	Q13352	GRB2	Homo sapiens	P62993	Y2H Pooling	32814053
Intra	ITGB3BP	Q13352	GRB2	Homo sapiens	P62993	Validated Y2H	32814053
Intra	ITGB3BP	Q13352	LSAMP	Homo sapiens	Q13449	Y2H Pooling	32814053
Intra	ITGB3BP	Q13352	LSAMP	Homo sapiens	Q13449	Validated Y2H	32814053
Intra	ITGB3BP	Q13352	LSAMP	Homo sapiens	Q13449	Y2H Array	32814053
Intra	ITGB3BP	Q13352	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	25416956
Intra	ITGB3BP	Q13352	ARFIP2	Homo sapiens	P53365	Y2H Pooling	16189514
Intra	ITGB3BP	Q13352	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	ITGB3BP	Q13352	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	ITGB3BP	Q13352	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	CERT1	Homo sapiens	Q9Y5P4	Y2H Prey Pooling	25416956
Intra	ITGB3BP	Q13352	CERT1	Homo sapiens	Q9Y5P4	Y2H Pooling	16189514
Intra	ITGB3BP	Q13352	CERT1	Homo sapiens	Q9Y5P4	Validated Y2H	25416956
Intra	ITGB3BP	Q13352	CERT1	Homo sapiens	Q9Y5P4	Y2H Array	25416956
Intra	ITGB3BP	Q13352	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	ITGB3BP	Q13352	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06967	ITGB3BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ITGB3BP	VGNC	VGNC:67851
Mus musculus	ITGB3BP	MGD	MGI:1914983
Canis familiaris	ITGB3BP	VGNC	VGNC:53418
Rattus norvegicus	ITGB3BP	RGD	RGD:1310044
Macaca mulatta	ITGB3BP	VGNC	VGNC:73787
Bos taurus	ITGB3BP	VGNC	VGNC:30328
Others	ITGB3BP	NCBI