CENPU - centromere protein U Gene

Also Known as KLIP1; PBIP1; CENP50; MLF1IP; CENPU50

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79682

About CENPU

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,694,085-184,734,096 (from NCBI)

This gene has 6 transcripts (splice variants) and 169 orthologues. Biased expression in testis (RPKM 44.2), bone marrow (RPKM 27.7) and 10 other tissues.

Summary

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during Mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

CENPU Products (1)

mRNA	Protein	Name
NM_024629.4	NP_078905.2	centromere protein U

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19597481	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPU Protein Structure

CENP-U

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
centromere protein U	KSHV latent nuclear antigen interacting protein 1

CENPU Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPU	Q71F23	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	CENPU	Q71F23	CENPQ	Homo sapiens	Q7L2Z9	Anti Tag CoIP	33961781
Intra	CENPU	Q71F23	CENPQ	Homo sapiens	Q7L2Z9	Anti Tag CoIP	26496610
Intra	CENPU	Q71F23	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	25416956
Intra	CENPU	Q71F23	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	CENPU	Q71F23	ITGB3BP	Homo sapiens	Q13352	Anti Tag CoIP	33961781
Intra	CENPU	Q71F23	ITGB3BP	Homo sapiens	Q13352	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperinsulinemic Hypoglycemia, Familial, 3	HHF3 Hyperinsulinism Due To Glucokinase Deficiency Familial Hyperinsulinemic Hypoglycemia 3 Hyperinsulinemic Hypoglycemia Due To Glucokinase Deficiency Hyperinsulinemic Hypoglycemia Familial 3 Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hypoglycemia, Hyperinsulinemic, Familial, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02492	CENPU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CENPU	VGNC	VGNC:60762
Rattus norvegicus	CENPU	RGD	RGD:1562566
Bos taurus	CENPU	VGNC	VGNC:27186
Mus musculus	CENPU	MGD	MGI:1919126
Macaca mulatta	CENPU	VGNC	VGNC:71068
Canis familiaris	CENPU	VGNC	VGNC:39113
Others	CENPU	NCBI