2. Gene
  3. CENPU - centromere protein U Gene

CENPU - centromere protein U Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KLIP1; PBIP1; CENP50; MLF1IP; CENPU50

Gene ID: 79682 | Gene type: protein coding

About CENPU

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,694,085-184,734,096 (from NCBI)

This gene has 6 transcripts (splice variants) and 169 orthologues. Biased expression in testis (RPKM 44.2), bone marrow (RPKM 27.7) and 10 other tissues.

Summary

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

CENPU Products(1)

mRNA Protein Name
NM_024629.4 NP_078905.2 centromere protein U

CENPU Protein Structure

CENP-U

CENP-U: CENP-A nucleosome associated complex (NAC) subunit (143 - 320)

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  • 418 a.a.
Protein Preferred Names Protein Names

centromere protein U

KSHV latent nuclear antigen interacting protein 1

Related Diseases

Diseases Alias
Hyperinsulinemic Hypoglycemia, Familial, 3

HHF3

Hyperinsulinism Due To Glucokinase Deficiency

Familial Hyperinsulinemic Hypoglycemia 3

Hyperinsulinemic Hypoglycemia Due To Glucokinase Deficiency

Hyperinsulinemic Hypoglycemia Familial 3

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hypoglycemia, Hyperinsulinemic, Familial, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02492 CENPU Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CENPU VGNC VGNC:60762
Rattus norvegicus CENPU RGD RGD:1562566
Bos taurus CENPU VGNC VGNC:27186
Mus musculus CENPU MGD MGI:1919126
Macaca mulatta CENPU VGNC VGNC:71068
Canis familiaris CENPU VGNC VGNC:39113