ARFIP2 - ARF interacting protein 2 Gene
Also Known as POR1
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 23647
Summary
Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin Cytoskeleton organization; mitophagy; and protein localization to phagophore assembly site. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues.
ARFIP2 Products (17)
| mRNA | Protein | Name |
|---|---|---|
| NM_001242854.3 | NP_001229783.1 | arfaptin-2 isoform 1 |
| NM_001242855.3 | NP_001229784.1 | arfaptin-2 isoform 3 |
| NM_001242856.3 | NP_001229785.1 | arfaptin-2 isoform 4 precursor |
| NM_001370406.2 | NP_001357335.1 | arfaptin-2 isoform 5 |
| NM_001370408.2 | NP_001357337.1 | arfaptin-2 isoform 3 |
| NM_001370409.2 | NP_001357338.1 | arfaptin-2 isoform 7 |
| NM_001370411.2 | NP_001357340.1 | arfaptin-2 isoform 7 |
| NM_001370412.2 | NP_001357341.1 | arfaptin-2 isoform 8 |
| NM_001370413.2 | NP_001357342.1 | arfaptin-2 isoform 8 |
| NM_001376558.2 | NP_001363487.1 | arfaptin-2 isoform 2 |
| NM_001376559.2 | NP_001363488.1 | arfaptin-2 isoform 5 |
| NM_001376560.2 | NP_001363489.1 | arfaptin-2 isoform 10 |
| NM_001376561.2 | NP_001363490.1 | arfaptin-2 isoform 11 |
| NM_001376562.2 | NP_001363491.1 | arfaptin-2 isoform 12 precursor |
| NM_001376563.2 | NP_001363492.1 | arfaptin-2 isoform 3 |
| NM_001376564.2 | NP_001363493.1 | arfaptin-2 isoform 13 |
| NM_012402.5 | NP_036534.1 | arfaptin-2 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTP-dependent protein binding |
IPI
IPI: Inferred from physical interaction
|
9312003 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
8670882 | GOA |
| enables membrane curvature sensor activity |
IDA
IDA: Inferred from direct assay
|
29768204 | GOA |
| enables phosphatidylinositol-4-phosphate binding |
IDA
IDA: Inferred from direct assay
|
23695357 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8670882 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in actin cytoskeleton organization |
IMP
IMP: Inferred from mutant phenotype
|
9312003 | GOA |
| involved in mitophagy |
IMP
IMP: Inferred from mutant phenotype
|
33773106 | GOA |
| involved in protein localization to phagophore assembly site |
IMP
IMP: Inferred from mutant phenotype
|
33773106 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell cortex |
IDA
IDA: Inferred from direct assay
|
9312003 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
25468996 | GOA |
| located in ruffle |
IMP
IMP: Inferred from mutant phenotype
|
8670882 | GOA |
| located in trans-Golgi network membrane |
IDA
IDA: Inferred from direct assay
|
23695357 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
ARFIP2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ARFIP2 | P53365 | ITGB3BP | Homo sapiens | Q13352-5 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | ITGB3BP | Homo sapiens | Q13352-5 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | NRDE2 | Homo sapiens | Q9H7Z3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | NRDE2 | Homo sapiens | Q9H7Z3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | NRDE2 | Homo sapiens | Q9H7Z3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | AGTRAP | Homo sapiens | Q6RW13-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | AGTRAP | Homo sapiens | Q6RW13-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | AGTRAP | Homo sapiens | Q6RW13-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CYTH3 | Homo sapiens | O43739-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CYTH3 | Homo sapiens | O43739-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | NDRG4 | Homo sapiens | Q9ULP0-2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | MIEF2 | Homo sapiens | Q96C03-3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DGAT2L6 | Homo sapiens | Q6ZPD8 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DGAT2L6 | Homo sapiens | Q6ZPD8 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DGAT2L6 | Homo sapiens | Q6ZPD8 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GSG1 | Homo sapiens | Q2KHT4-3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GSG1 | Homo sapiens | Q2KHT4-3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GSG1 | Homo sapiens | Q2KHT4-3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REEP5 | Homo sapiens | Q00765 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REEP5 | Homo sapiens | Q00765 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | REEP5 | Homo sapiens | Q00765 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | HAUS1 | Homo sapiens | Q96CS2 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | HAUS1 | Homo sapiens | Q96CS2 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | SH3GLB1 | Homo sapiens | Q9Y371 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
ARFIP2 | P53365 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
ARFIP2 | P53365 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
ARFIP2 | P53365 | PKNOX2 | Homo sapiens | Q96KN3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PKNOX2 | Homo sapiens | Q96KN3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PKNOX2 | Homo sapiens | Q96KN3 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SCAMP5 | Homo sapiens | Q8TAC9 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SCAMP5 | Homo sapiens | Q8TAC9 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SCAMP5 | Homo sapiens | Q8TAC9 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP1 | Homo sapiens | P53367 | 35271311 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP1 | Homo sapiens | P53367 | 33961781 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP1 | Homo sapiens | P53367 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CDR1 | Homo sapiens | P51861 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CDR1 | Homo sapiens | P51861 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | TMEM255B | Homo sapiens | Q8WV15 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SMG9 | Homo sapiens | Q9H0W8 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | FADS6 | Homo sapiens | Q8N9I5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | FADS6 | Homo sapiens | Q8N9I5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | FADS6 | Homo sapiens | Q8N9I5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DMAP1 | Homo sapiens | Q9NPF5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DMAP1 | Homo sapiens | Q9NPF5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | DMAP1 | Homo sapiens | Q9NPF5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | RAC1 | Homo sapiens | P63000 | 8670882 | |
|
Intra
|
ARFIP2 | P53365 | RAC1 | Homo sapiens | P63000 | 21988832 | |
|
Intra
|
ARFIP2 | P53365 | RAC1 | Homo sapiens | P63000 | 9312003 | |
|
Intra
|
ARFIP2 | P53365 | RND1 | Homo sapiens | Q92730 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | BLOC1S2 | Homo sapiens | Q6QNY1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | BLOC1S2 | Homo sapiens | Q6QNY1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | BLOC1S2 | Homo sapiens | Q6QNY1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ING5 | Homo sapiens | Q8WYH8 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | RAC2 | Homo sapiens | P15153 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | RAC2 | Homo sapiens | P15153 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | FSD2 | Homo sapiens | A1L4K1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | FSD2 | Homo sapiens | A1L4K1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PLP2 | Homo sapiens | Q04941 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PLP2 | Homo sapiens | Q04941 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PLP2 | Homo sapiens | Q04941 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARF6 | Homo sapiens | P62330 | 9312003 | |
|
Intra
|
ARFIP2 | P53365 | ARF6 | Homo sapiens | P62330 | 9312003 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 8670882 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | ARFIP2 | Homo sapiens | P53365 | 31515488 | |
|
Intra
|
ARFIP2 | P53365 | ITGB3BP | Homo sapiens | Q13352 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | ITGB3BP | Homo sapiens | Q13352 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | USHBP1 | Homo sapiens | Q8N6Y0 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | MIEF1 | Homo sapiens | Q9NQG6 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | PBX3 | Homo sapiens | Q96AL5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | AGTRAP | Homo sapiens | Q6RW13 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | AGTRAP | Homo sapiens | Q6RW13 | 21516116 | |
|
Intra
|
ARFIP2 | P53365 | C19orf25 | Homo sapiens | Q9UFG5 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | CEP63 | Homo sapiens | Q96MT8 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | CEP63 | Homo sapiens | Q96MT8 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | CEP63 | Homo sapiens | Q96MT8 | 25416956 | |
|
Intra
|
ARFIP2 | P53365 | RAC3 | Homo sapiens | P60763 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | RAC3 | Homo sapiens | P60763 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | RAC3 | Homo sapiens | P60763 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SYP | Homo sapiens | P08247 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SYP | Homo sapiens | P08247 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | MAL2 | Homo sapiens | Q969L2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | MAL2 | Homo sapiens | Q969L2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | MAL2 | Homo sapiens | Q969L2 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SCAMP1 | Homo sapiens | O15126 | 32296183 | |
|
Intra
|
ARFIP2 | P53365 | SCAMP1 | Homo sapiens | O15126 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS00905 | ARFIP1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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