ARFIP1 - ADP ribosylation factor interacting protein 1 Gene

Also Known as HSU52521

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27236

About ARFIP1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:152,779,954-152,912,357 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 8.9), colon (RPKM 8.5) and 25 other tissues.

Summary

Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARFIP1 Products (6)

mRNA Protein Name
NM_001025593.3 NP_001020764.1 arfaptin-1 isoform 2
NM_001025595.3 NP_001020766.1 arfaptin-1 isoform 1
NM_001287431.2 NP_001274360.1 arfaptin-1 isoform 1
NM_001287432.2 NP_001274361.1 arfaptin-1 isoform 1
NM_001287433.2 NP_001274362.1 arfaptin-1 isoform 2
NM_014447.4 NP_055262.1 arfaptin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
23695357 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22981988 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within intracellular protein transport IDA
IDA: Inferred from direct assay
12606037 GOA
involved in negative regulation of retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
25789876 GOA
acts upstream of or within regulation of protein secretion IDA
IDA: Inferred from direct assay
12606037 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
9038142 GOA
located in cytosol IDA
IDA: Inferred from direct assay
9038142 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
23695357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARFIP1 Protein Structure

Arfaptin

Arfaptin: Arfaptin-like domain (123 - 348)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

arfaptin-1

ARFIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Validated Y2H
32296183
Intra
ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Y2H Array
32296183
Intra
ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Validated Y2H
32296183
Intra
ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra
ARFIP1 P53367 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
ARFIP1 P53367 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra
ARFIP1 P53367 ARL1 Homo sapiens P40616
Pull Down
22981988
Intra
ARFIP1 P53367 ARL1 Homo sapiens P40616
Anti Tag CoIP
35271311
Intra
ARFIP1 P53367 ARL1 Homo sapiens P40616
Anti Tag CoIP
22981988
Intra
ARFIP1 P53367 SYNGR3 Homo sapiens O43761
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SYNGR3 Homo sapiens O43761
Y2H Array
32296183
Intra
ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 PRKD1 Homo sapiens Q15139
Protein Kinase Assay
22981988
Intra
ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Y2H Array
32296183
Intra
ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Validated Y2H
32296183
Intra
ARFIP1 P53367 SMPD2 Homo sapiens O60906
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SMPD2 Homo sapiens O60906
Y2H Array
32296183
Intra
ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Validated Y2H
32296183
Intra
ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Y2H Array
32296183
Intra
ARFIP1 P53367 AFF1 Homo sapiens P51825-3
Y2H Array
32296183
Intra
ARFIP1 P53367 AFF1 Homo sapiens P51825-3
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Validated Y2H
32296183
Intra
ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
Intra
ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
ARFIP1 P53367 ARF1 Homo sapiens P84077
Pull Down
22981988
Intra
ARFIP1 P53367 ARF1 Homo sapiens P84077
Anti Tag CoIP
22981988
Intra
ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Y2H Array
32296183
Intra
ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Anti Tag CoIP
35271311
Intra
ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Validated Y2H
32296183
Intra
ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
ARFIP1 P53367 SCAMP1 Homo sapiens O15126
Y2H Array
32296183
Intra
ARFIP1 P53367 SCAMP1 Homo sapiens O15126
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ARFIP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811033 ARFIP1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P89807 arfaptin 1 Antibody (YA9151) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00905 ARFIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARFIP1 VGNC VGNC:38038
Mus musculus ARFIP1 MGD MGI:1277120
Macaca mulatta ARFIP1 VGNC VGNC:69878
Felis catus ARFIP1 VGNC VGNC:59871
Bos taurus ARFIP1 VGNC VGNC:26067
Rattus norvegicus ARFIP1 RGD RGD:708401
Others ARFIP1 NCBI