PRKD1 - protein kinase D1 Gene

Also Known as PKD; PKCM; CHDED; PRKCM; PKC-MU

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5587

About PRKD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:29,576,479-29,927,847 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 3.2), prostate (RPKM 2.7) and 22 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]

PRKD1 Products (7)

mRNA	Protein	Name
NM_002742.3	NP_002733.2	serine/threonine-protein kinase D1 isoform 2
XR_943493.3
XM_047431589.1	XP_047287545.1	serine/threonine-protein kinase D1 isoform X1
NM_001330069.2	NP_001316998.1	serine/threonine-protein kinase D1 isoform 1
XM_047431590.1	XP_047287546.1	serine/threonine-protein kinase D1 isoform X3
NM_001348390.1	NP_001335319.1	serine/threonine-protein kinase D1 isoform 3
XM_011536965.3	XP_011535267.1	serine/threonine-protein kinase D1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12637538	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10831594	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	24623306	GOA
enables phosphatidylinositol 3-kinase activator activity	IDA IDA: Inferred from direct assay	22095288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10831594	GOA
enables protein serine kinase activity	IGI IGI: Inferred from genetic interaction	20497126	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18440775	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28428613	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	19211839	GOA
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in cellular response to hydroperoxide	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	12505989	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12505989	GOA
involved in positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18332134	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12505989	GOA
involved in positive regulation of endothelial cell chemotaxis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18332134	GOA
involved in positive regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	19211839	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	22095288	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	24623306	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18059339	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11239398	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	22095288	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19211839	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKD1 Protein Structure

C1_1

Pkinase

0
200
400
600
800
912 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase D1	nPKC-D1 nPKC-mu protein kinase C mu type protein kinase C, mu protein kinase D

PRKD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKD1	Q15139	C1QBP	Homo sapiens	Q07021	Pull Down	10831594
Intra	PRKD1	Q15139	C1QBP	Homo sapiens	Q07021	Anti Bait CoIP	10831594
Intra	PRKD1	Q15139	PRKD3	Homo sapiens	O94806	Anti Tag CoIP	33961781
Intra	PRKD1	Q15139	MAPK13	Homo sapiens	O15264	Anti Tag CoIP	19135240
Intra	PRKD1	Q15139	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKD1	Q15139	CDH1	Homo sapiens	P12830	Confocal	15695390
Intra	PRKD1	Q15139	CDH1	Homo sapiens	P12830	Anti Bait CoIP	15695390
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Y2H	14550308
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Beta Galactosidase	14550308
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Confocal	14550308

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKD1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81914	PKD1 Antibody (YA1659)	WB	Human, Rat
HY-P81914A	PKD1 Antibody (YA1659)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Congenital Heart Defects And Ectodermal Dysplasia	CHDED Heart Defects, Congenital And Ectodermal Dysplasia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Spermatogenic Failure 6	Globozoospermia SPGF6 Round-Headed Spermatozoa Acrosome Malformation Of Spermatozoa Spermatogenic Failure 9 Spermatozoa, Round-Headed Globozoospermia, Complete Globozoospermia, Total Mae Infertility Due To Round-Headed Spermatozoa Male Infertility Due To Globozoospermia Male Infertility Due To Round-Headed Spermatozoa Round-Headed Sperm Syndrome Spgf9 Teratozoospermia
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Caroli Disease	Caroli Disease Isolated Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts Cystic Dilatation Of The Intrahepatic Biliary Tree Caroli Syndrome Carolis Disease
Congenital Nonspherocytic Hemolytic Anemia	Hereditary Nonspherocytic Hemolytic Anemia Hereditary Non-Spherocytic Hemolytic Anemia Anemia, Hemolytic, Congenital Nonspherocytic Congenital Nonspherocytic Hemolytic Anaemia Hereditary Nonspherocytic Hemolytic Anaemia Hnsha
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Episodic Kinesigenic Dyskinesia 1	Paroxysmal Kinesigenic Choreoathetosis Paroxysmal Kinesigenic Dyskinesia Dystonia 10 Familial Paroxysmal Kinesigenic Dyskinesia Episodic Kinesigenic Dyskinesia EKD1 Pkc Pkd Dyt10 Familial Pkd Paroxysmal Kinesigenic Choreathetosis Familial Paroxysmal Dystonia Dystonia, Familial Paroxysmal Dyt-Prrt2 Dystonia, Type 10
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11144	PRKD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11145	Prkd1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11146	Prkd1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKD1	VGNC	VGNC:53949
Mus musculus	PRKD1	MGD	MGI:99879
Felis catus	PRKD1	VGNC	VGNC:69065
Rattus norvegicus	PRKD1	RGD	RGD:620964
Canis familiaris	PRKD1	VGNC	VGNC:44986
Macaca mulatta	PRKD1	VGNC	VGNC:76414
Others	PRKD1	NCBI