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SYNGR3 - synaptogyrin 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9143

About SYNGR3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,989,970-1,994,275 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 3 paralogues. Biased expression in brain (RPKM 26.0), adrenal (RPKM 4.5) and 2 other tissues.

Summary

This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the Dopamine Transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]

SYNGR3 Products (1)

mRNA	Protein	Name
NM_004209.6	NP_004200.2	synaptogyrin-3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNGR3 Protein Structure

MARVEL

0
100
200
229 a.a.

Protein Preferred Names	Protein Names
synaptogyrin-3

SYNGR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYNGR3	O43761	TTPA	Homo sapiens	P49638	Validated Y2H	32296183
Intra	SYNGR3	O43761	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	SYNGR3	O43761	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	SYNGR3	O43761	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	SYNGR3	O43761	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	SYNGR3	O43761	ARFIP1	Homo sapiens	P53367	Validated Y2H	32296183
Intra	SYNGR3	O43761	ACSF2	Homo sapiens	Q96CM8	Validated Y2H	32296183
Intra	SYNGR3	O43761	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	SYNGR3	O43761	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	SYNGR3	O43761	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	SYNGR3	O43761	MPP1	Homo sapiens	Q00013	Validated Y2H	32296183
Intra	SYNGR3	O43761	MIDN	Homo sapiens	Q504T8	Validated Y2H	32296183
Intra	SYNGR3	O43761	PLIN3	Homo sapiens	O60664	Validated Y2H	32296183
Intra	SYNGR3	O43761	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	SYNGR3	O43761	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	SYNGR3	O43761	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	SYNGR3	O43761	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	SYNGR3	O43761	GAD2	Homo sapiens	Q05329	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 86	DFNB86 Autosomal Recessive Nonsyndromic Deafness 86 Autosomal Recessive Deafness 86 Deafness, Autosomal Recessive, 86 Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Generalized Atherosclerosis	Generalised Atherosclerosis
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14092	SYNGR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SYNGR3	VGNC	VGNC:80687
Macaca mulatta	SYNGR3	VGNC	VGNC:78069
Rattus norvegicus	SYNGR3	RGD	RGD:1311801
Mus musculus	SYNGR3	MGD	MGI:1341881
Bos taurus	SYNGR3	VGNC	VGNC:35525
Others	SYNGR3	NCBI