MIDN - midnolin Gene

Also Known as Stx

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90007

About MIDN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,248,583-1,259,143 (from NCBI)

This gene has 5 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in bone marrow (RPKM 27.5), gall bladder (RPKM 18.8) and 25 other tissues.

Summary

Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of Glucokinase activity and negative regulation of Insulin secretion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MIDN Products (4)

mRNA Protein Name
NM_001388306.1 NP_001375235.1 midnolin isoform 1
NM_001388307.1 NP_001375236.1 midnolin isoform 3
NM_001388474.1 NP_001375403.1 midnolin isoform 2
NM_177401.5 NP_796375.3 midnolin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
37616343 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasomal ubiquitin-independent protein catabolic process IDA
IDA: Inferred from direct assay
37616343 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24187134 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24187134 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIDN Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (40 - 99)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

midnolin

  • midbrain nucleolar protein

MIDN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIDN Q504T8 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
MIDN Q504T8 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
MIDN Q504T8 SYNGR3 Homo sapiens O43761
Y2H Prey Pooling
32296183
Intra
MIDN Q504T8 SYNGR3 Homo sapiens O43761
Y2H Array
32296183
Intra
MIDN Q504T8 CMTM4 Homo sapiens Q8IZR5-2
Validated Y2H
32296183
Intra
MIDN Q504T8 CMTM4 Homo sapiens Q8IZR5-2
Y2H Array
32296183
Intra
MIDN Q504T8 CMTM4 Homo sapiens Q8IZR5-2
Y2H Prey Pooling
32296183
Intra
MIDN Q504T8 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
MIDN Q504T8 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
MIDN Q504T8 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08438 MIDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MIDN RGD RGD:1309629
Canis familiaris MIDN VGNC VGNC:43225
Bos taurus MIDN VGNC VGNC:31466
Felis catus MIDN VGNC VGNC:102638
Mus musculus MIDN MGD MGI:1890222
Macaca mulatta MIDN VGNC VGNC:82186
Others MIDN NCBI