MPP1 - MAGUK p55 scaffold protein 1 Gene

Homo sapiens

Also known as MRG1; PEMP; AAG12; EMP55; DXS552E

Gene ID: 4354 | Gene type: protein coding

About MPP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,778,684-154,805,485 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 7 paralogues. Broad expression in placenta (RPKM 52.9), bone marrow (RPKM 48.1) and 25 other tissues.

Summary

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the Cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

MPP1 Products(4)

mRNA	Protein	Name
NM_001166460.2	NP_001159932.1	55 kDa erythrocyte membrane protein isoform 2
NM_001166461.2	NP_001159933.1	55 kDa erythrocyte membrane protein isoform 3
NM_001166462.2	NP_001159934.1	55 kDa erythrocyte membrane protein isoform 4
NM_002436.4	NP_002427.1	55 kDa erythrocyte membrane protein isoform 1

MPP1 Protein Structure

PDZ

SH3_2

Guanylate_kin

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

55 kDa erythrocyte membrane protein

aging-associated gene 12

Related Diseases

Diseases

Alias

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08622	MPP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPP1	VGNC	VGNC:31582
Mus musculus	MPP1	MGD	MGI:105941
Macaca mulatta	MPP1	VGNC	VGNC:74920
Rattus norvegicus	MPP1	RGD	RGD:1594331
Canis familiaris	MPP1	VGNC	VGNC:43342
Felis catus	MPP1	VGNC	VGNC:101461