DNPEP - aspartyl aminopeptidase Gene

Also Known as DAP; ASPEP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23549

About DNPEP

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,372,043-219,400,007 (from NCBI)

This gene has 21 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in small intestine (RPKM 15.5), duodenum (RPKM 15.4) and 25 other tissues.

Summary

The protein encoded by this gene is an Aminopeptidase which prefers acidic Amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DNPEP Products (8)

mRNA Protein Name
NM_001319116.2 NP_001306045.1 aspartyl aminopeptidase isoform a
NM_001319117.2 NP_001306046.1 aspartyl aminopeptidase isoform b
NM_001319118.2 NP_001306047.1 aspartyl aminopeptidase isoform d
NM_001319119.2 NP_001306048.1 aspartyl aminopeptidase isoform d
NM_001319120.2 NP_001306049.1 aspartyl aminopeptidase isoform e
NM_001319121.2 NP_001306050.1 aspartyl aminopeptidase isoform f
NM_001319122.2 NP_001306051.1 aspartyl aminopeptidase isoform f
NM_012100.4 NP_036232.2 aspartyl aminopeptidase isoform c

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNPEP Protein Structure

Peptidase_M18

Peptidase_M18: Aminopeptidase I zinc metalloprotease (M18) (34 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

aspartyl aminopeptidase

DNPEP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNPEP Q9ULA0 MPP1 Homo sapiens Q00013
Validated Y2H
25416956
Intra
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
DNPEP Q9ULA0 SCAF8 Homo sapiens Q9UPN6
Anti Tag CoIP
33961781
Intra
DNPEP Q9ULA0 SCAF8 Homo sapiens Q9UPN6
Anti Tag CoIP
28514442
Intra
DNPEP Q9ULA0 TAE1 Saccharomyces cerevisiae P38340
Validated Y2H
27107014
Intra
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Prey Pooling
32296183
Intra
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Validated Y2H
32296183
Intra
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Array
25416956
Intra
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichorhinophalangeal Syndrome, Type I

  • Trichorhinophalangeal Dysplasia Type I

  • TRPS1

  • Trichorhinophalangeal Syndrome Type I

  • Trps I

  • Trichorhinophalangeal Syndrome Type 1

  • Type I Trichorhinophalangeal Syndrome

  • Giedion Syndrome

  • Trp Syndrome

  • Tricho-Rhino-Phalangeal Syndrome 1

  • Trichorhinophalangeal Syndrome, Type Iii
Nemaline Myopathy 9

  • NEM9

  • Myopathy, Nemaline, Type 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03914 DNPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DNPEP VGNC VGNC:28148
Macaca mulatta DNPEP VGNC VGNC:71961
Mus musculus DNPEP MGD MGI:1278328
Rattus norvegicus DNPEP RGD RGD:1583848
Canis familiaris DNPEP VGNC VGNC:40038
Felis catus DNPEP VGNC VGNC:61564
Others DNPEP NCBI