SCAF8 - SR-related CTD associated factor 8 Gene

Also Known as RBM16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22828

Summary

Enables RNA binding activity and RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled and positive regulation of DNA-templated transcription, elongation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in testis (RPKM 16.9), bone marrow (RPKM 14.1) and 25 other tissues.

SCAF8 Products (5)

mRNA Protein Name
NM_001286188.1 NP_001273117.1 SR-related and CTD-associated factor 8 isoform a
NM_001286189.1 NP_001273118.1 SR-related and CTD-associated factor 8 isoform b
NM_001286194.1 NP_001273123.1 SR-related and CTD-associated factor 8 isoform c
NM_001286199.2 NP_001273128.1 SR-related and CTD-associated factor 8 isoform d
NM_014892.5 NP_055707.3 SR-related and CTD-associated factor 8 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
31104839 GOA
enables RNA polymerase II C-terminal domain phosphoserine binding IDA
IDA: Inferred from direct assay
31104839 GOA
enables RNA polymerase core enzyme binding IPI
IPI: Inferred from physical interaction
18550522 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled IDA
IDA: Inferred from direct assay
31104839 GOA
involved in positive regulation of DNA-templated transcription, elongation IDA
IDA: Inferred from direct assay
31104839 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
31104839 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAF8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCAF8 Q9UPN6 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra
SCAF8 Q9UPN6 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra
SCAF8 Q9UPN6 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
SCAF8 Q9UPN6 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
SCAF8 Q9UPN6 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-121667 Scaff10-8 Inhibitor 99.11% Unkown
HY-RS03568 DCAF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12474 SCAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12475 SCAF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12476 SCAF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown