PLIN3 - perilipin 3 Gene

Also Known as PP17; TIP47; M6PRBP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10226

About PLIN3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,838,341-4,867,667 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 42.9), small intestine (RPKM 31.3) and 24 other tissues.

Summary

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the Ras oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

PLIN3 Products (3)

mRNA Protein Name
NM_001164189.2 NP_001157661.1 perilipin-3 isoform 2
NM_001164194.2 NP_001157666.1 perilipin-3 isoform 3
NM_005817.5 NP_005808.3 perilipin-3 isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19490898 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
34077757 GOA
involved in lipid droplet disassembly IDA
IDA: Inferred from direct assay
34077757 GOA
involved in lipid storage IDA
IDA: Inferred from direct assay
34077757 GOA
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
14741744 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLIN3 Protein Structure

Perilipin

Perilipin: Perilipin family (13 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

perilipin-3

  • 47 kDa MPR-binding protein

PLIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLIN3 O60664 TARS2 Homo sapiens Q9BW92 32296183
Intra
PLIN3 O60664 SNX2 Homo sapiens O60749 32296183
Intra
PLIN3 O60664 LNPK Homo sapiens Q9C0E8-2 32296183
Intra
PLIN3 O60664 SYNGR3 Homo sapiens O43761 32296183
Intra
PLIN3 O60664 SYNGR3 Homo sapiens O43761 32296183
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9-2 32296183
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9-2 32296183
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9-2 32296183
Intra
PLIN3 O60664 SYNGR1 Homo sapiens O43759-2 32296183
Intra
PLIN3 O60664 SYNGR1 Homo sapiens O43759-2 32296183
Intra
PLIN3 O60664 TBC1D13 Homo sapiens Q9NVG8 32296183
Intra
PLIN3 O60664 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
PLIN3 O60664 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
PLIN3 O60664 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
PLIN3 O60664 TMEM14C Homo sapiens Q9P0S9 32296183
Intra
PLIN3 O60664 TMEM14C Homo sapiens Q9P0S9 32296183
Intra
PLIN3 O60664 TMEM14C Homo sapiens Q9P0S9 32296183
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9 25416956
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9 25416956
Intra
PLIN3 O60664 CMTM5 Homo sapiens Q96DZ9 25416956
Intra
PLIN3 O60664 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
PLIN3 O60664 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
PLIN3 O60664 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
PLIN3 O60664 PIAS3 Homo sapiens Q9Y6X2 32296183
Intra
PLIN3 O60664 ABHD5 Homo sapiens Q8WTS1 32296183
Intra
PLIN3 O60664 SNX1 Homo sapiens Q13596 32296183
Intra
PLIN3 O60664 SNX1 Homo sapiens Q13596 32296183
Intra
PLIN3 O60664 CCNC Homo sapiens P24863 32296183
Intra
PLIN3 O60664 SFT2D2 Homo sapiens O95562 32296183
Intra
PLIN3 O60664 SFT2D2 Homo sapiens O95562 32296183
Intra
PLIN3 O60664 SFT2D2 Homo sapiens O95562 32296183
Intra
PLIN3 O60664 MYG1 Homo sapiens Q9HB07 32296183
Intra
PLIN3 O60664 ABHD4 Homo sapiens Q8TB40 32296183
Intra
PLIN3 O60664 MIEF1 Homo sapiens Q9NQG6 32296183
Intra
PLIN3 O60664 PBX3 Homo sapiens Q96AL5 32296183
Intra
PLIN3 O60664 PTPN9 Homo sapiens P43378 32296183
Intra
PLIN3 O60664 CHMP4B Homo sapiens Q9H444 32296183
Intra
PLIN3 O60664 SYP Homo sapiens P08247 32296183
Intra
PLIN3 O60664 SYP Homo sapiens P08247 32296183
Intra
PLIN3 O60664 SYP Homo sapiens P08247 32296183
Intra
PLIN3 O60664 GAD2 Homo sapiens Q05329 32296183
Cross
PLIN3 O60664 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H
23593007
Cross: Cross-species interaction Intra: Intraspecies interaction

PLIN3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83852 PLIN3 Antibody (YA3549) WB, ICC/IF, FC Human
HY-P83852A PLIN3 Antibody (YA3549)(PBS only) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Suppressor Of Tumorigenicity 3
  • Cervical Carcinoma

  • ST3

  • Tumor-Suppressor Gene, Hela Cell Type

  • Tshl

  • Cervical Carcinoma, Tumor-Suppressor Gene Involved In

  • Ccts

  • Cervix Carcinoma

Chanarin-Dorfman Syndrome
  • Neutral Lipid Storage Disease

  • CDS

  • Neutral Lipid Storage Disease With Ichthyosis

  • Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

  • Triglyceride Storage Disease With Ichthyosis

  • Nlsdi

  • Ichthyotic Neutral Lipid Storage Disease

  • Dorfman-Chanarin Syndrome

  • Dcs

  • Chanarin-Dorfman Disease

  • Ichthyosiform Erythroderma With Leukocyte Vacuolation

  • Lipidosis With Triglyceride Storage Disease

  • Disorder Of Cornification 12

  • Dorfman Chanarin Syndrome

  • Neutral Lipid Storage Disease With Ichthyotic

  • Dorfman-Chanarin Disease

Spastic Paraplegia 20, Autosomal Recessive
  • Troyer Syndrome

  • SPG20

  • Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting

  • Spastic Paraplegia, Autosomal Recessive, Troyer Type

  • Autosomal Recessive Spastic Paraplegia Type 20

  • Autosomal Recessive Hereditary Spastic Paraplegia

  • Spastic Paraplegia 20

  • Cross-Mckusick Syndrome

  • Autosomal Recessive Spastic Paraplegia 20

  • Autosomal Recessive Spastic Paraplegia Troyer Type

  • Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting

  • Hereditary Spastic Paraplegia 20

  • Spastic Paraplegia Type 20

  • Hereditary Spastic Paraplegia

  • Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome

  • Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting

  • Spastic Paraplegia Autosomal Recessive Troyer Type

  • Trs

  • Spastic Paraplegia Hereditary Autosomal Recessive

  • Spastic Paraplegia, Hereditary

Body Mass Index Quantitative Trait Locus 11
  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus PLIN3 VGNC VGNC:64241
Mus musculus PLIN3 MGD MGI:1914155
Rattus norvegicus PLIN3 RGD RGD:1595854
Canis familiaris PLIN3 VGNC VGNC:44692
Macaca mulatta PLIN3 VGNC VGNC:76038
Bos taurus PLIN3 VGNC VGNC:33031
Others PLIN3 NCBI