PLIN3 - perilipin 3 Gene
Also Known as PP17; TIP47; M6PRBP1
Species: Homo sapiens
About PLIN3
This gene has 7 transcripts (splice variants), 186 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 42.9), small intestine (RPKM 31.3) and 24 other tissues.
Summary
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the Ras oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
PLIN3 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001164189.2 | NP_001157661.1 | perilipin-3 isoform 2 |
| NM_001164194.2 | NP_001157666.1 | perilipin-3 isoform 3 |
| NM_005817.5 | NP_005808.3 | perilipin-3 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19490898 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cellular response to glucose starvation |
IDA
IDA: Inferred from direct assay
|
34077757 | GOA |
| involved in lipid droplet disassembly |
IDA
IDA: Inferred from direct assay
|
34077757 | GOA |
| involved in lipid storage |
IDA
IDA: Inferred from direct assay
|
34077757 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in lipid droplet |
IDA
IDA: Inferred from direct assay
|
14741744 | GOA |
PLIN3 Protein Structure
Perilipin: Perilipin family (13 - 412)
- 0
- 100
- 200
- 300
- 400
- 434 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
perilipin-3 |
|
PLIN3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PLIN3 | O60664 | TARS2 | Homo sapiens | Q9BW92 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SNX2 | Homo sapiens | O60749 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | LNPK | Homo sapiens | Q9C0E8-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYNGR3 | Homo sapiens | O43761 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYNGR3 | Homo sapiens | O43761 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYNGR1 | Homo sapiens | O43759-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYNGR1 | Homo sapiens | O43759-2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | TBC1D13 | Homo sapiens | Q9NVG8 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | TMEM14C | Homo sapiens | Q9P0S9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | TMEM14C | Homo sapiens | Q9P0S9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | TMEM14C | Homo sapiens | Q9P0S9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9 | 25416956 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9 | 25416956 | |
|
Intra
|
PLIN3 | O60664 | CMTM5 | Homo sapiens | Q96DZ9 | 25416956 | |
|
Intra
|
PLIN3 | O60664 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | PIAS3 | Homo sapiens | Q9Y6X2 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | ABHD5 | Homo sapiens | Q8WTS1 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SNX1 | Homo sapiens | Q13596 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SNX1 | Homo sapiens | Q13596 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CCNC | Homo sapiens | P24863 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SFT2D2 | Homo sapiens | O95562 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SFT2D2 | Homo sapiens | O95562 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SFT2D2 | Homo sapiens | O95562 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | MYG1 | Homo sapiens | Q9HB07 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | ABHD4 | Homo sapiens | Q8TB40 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | MIEF1 | Homo sapiens | Q9NQG6 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | PBX3 | Homo sapiens | Q96AL5 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | PTPN9 | Homo sapiens | P43378 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | CHMP4B | Homo sapiens | Q9H444 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYP | Homo sapiens | P08247 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYP | Homo sapiens | P08247 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | SYP | Homo sapiens | P08247 | 32296183 | |
|
Intra
|
PLIN3 | O60664 | GAD2 | Homo sapiens | Q05329 | 32296183 | |
|
Cross
|
PLIN3 | O60664 | Q9WMX2-PRO_0000037551 | Hepatitis C virus | Q9WMX2-PRO_0000037551 | 23593007 |
PLIN3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83852 | PLIN3 Antibody (YA3549) | WB, ICC/IF, FC | Human |
| HY-P83852A | PLIN3 Antibody (YA3549)(PBS only) | WB, ICC/IF, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Suppressor Of Tumorigenicity 3 |
|
|
| Chanarin-Dorfman Syndrome |
|
|
| Spastic Paraplegia 20, Autosomal Recessive |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | PLIN3 | VGNC | VGNC:64241 |
| Mus musculus | PLIN3 | MGD | MGI:1914155 |
| Rattus norvegicus | PLIN3 | RGD | RGD:1595854 |
| Canis familiaris | PLIN3 | VGNC | VGNC:44692 |
| Macaca mulatta | PLIN3 | VGNC | VGNC:76038 |
| Bos taurus | PLIN3 | VGNC | VGNC:33031 |
| Others | PLIN3 | NCBI |