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SNX2 - sorting nexin 2 Gene

Also Known as TRG-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6643

About SNX2

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:122,774,996-122,834,543 (from NCBI)

This gene has 13 transcripts (splice variants), 214 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 17.2), spleen (RPKM 14.1) and 25 other tissues.

Summary

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with Other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

SNX2 Products (2)

mRNA	Protein	Name
NM_001278199.1	NP_001265128.1	sorting nexin-2 isoform 2
NM_003100.4	NP_003091.2	sorting nexin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables leptin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables transferrin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lamellipodium morphogenesis	IDA IDA: Inferred from direct assay	20604901	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	20138391	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11279102	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15673616	GOA
located in membrane	IDA IDA: Inferred from direct assay	9819414	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9819414	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, tubulation complex	IPI IPI: Inferred from physical interaction	11102511	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX2 Protein Structure

Sorting_nexin

Vps5

0
100
200
300
400
519 a.a.

Protein Preferred Names	Protein Names
sorting nexin-2	CTB-36H16.2

SNX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX2	O60749	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	SNX2	O60749	FNBP1	Homo sapiens	Q96RU3	Y2H	14596906
Intra	SNX2	O60749	FNBP1	Homo sapiens	Q96RU3	Y2H	11438682
Intra	SNX2	O60749	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	SNX2	O60749	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	SNX2	O60749	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	CENPQ	Homo sapiens	Q7L2Z9	Validated Y2H	32296183
Intra	SNX2	O60749	CENPQ	Homo sapiens	Q7L2Z9	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
Intra	SNX2	O60749	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
Intra	SNX2	O60749	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	SNX2	O60749	SNX1	Homo sapiens	Q13596	Anti Tag CoIP	35271311
Intra	SNX2	O60749	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	SNX2	O60749	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	SNX2	O60749	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	SNX2	O60749	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	SNX2	O60749	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	SNX2	O60749	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	SNX2	O60749	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	SNX2	O60749	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	SNX2	O60749	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	32296183
Intra	SNX2	O60749	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	SNX2	O60749	SNX5	Homo sapiens	Q9Y5X3	Anti Tag CoIP	35271311
Intra	SNX2	O60749	SNX5	Homo sapiens	Q9Y5X3	Y2H	21988832
Intra	SNX2	O60749	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	SNX2	O60749	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	SNX2	O60749	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	SNX2	O60749	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	SNX2	O60749	SNX32	Homo sapiens	Q86XE0	Validated Y2H	32296183
Intra	SNX2	O60749	SNX6	Homo sapiens	Q9UNH7	Validated Y2H	32296183
Intra	SNX2	O60749	SNX6	Homo sapiens	Q9UNH7	Y2H Prey Pooling	32296183
Intra	SNX2	O60749	SNX6	Homo sapiens	Q9UNH7	Y2H Array	32296183
Intra	SNX2	O60749	SNX6	Homo sapiens	Q9UNH7	Anti Tag CoIP	35271311
Intra	SNX2	O60749	SNX6	Homo sapiens	Q9UNH7	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

SNX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810021	SNX2 Antibody (YA9365)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101800	Senexin B	Inhibitor	99.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117988	SNX2-1-108	Inhibitor	/	Unkown
HY-RS13533	SNX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SNX2	VGNC	VGNC:65550
Rattus norvegicus	SNX2	RGD	RGD:1310291
Canis familiaris	SNX2	VGNC	VGNC:46629
Macaca mulatta	SNX2	VGNC	VGNC:77682
Mus musculus	SNX2	MGD	MGI:1915054
Bos taurus	SNX2	VGNC	VGNC:35100
Others	SNX2	NCBI