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FNBP1 - formin binding protein 1 Gene

Also Known as FBP17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23048

About FNBP1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,887,187-130,053,879 (from NCBI)

This gene has 13 transcripts (splice variants), 286 orthologues, 2 paralogues and is associated with 65 phenotypes. Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

FNBP1 Products (3)

mRNA	Protein	Name
NM_001363755.1	NP_001350684.1	formin-binding protein 1 isoform 2
NM_001411018.1	NP_001397947.1	formin-binding protein 1 isoform 3
NM_015033.3	NP_055848.1	formin-binding protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15252009	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11438682	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNBP1 Protein Structure

FCH

SH3_9

0
100
200
300
400
500
617 a.a.

Protein Preferred Names	Protein Names
formin-binding protein 1	formin-binding protein 17

FNBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FNBP1	Q96RU3	SNX2	Homo sapiens	O60749	IF	14596906
Intra	FNBP1	Q96RU3	SNX2	Homo sapiens	O60749	Anti Tag CoIP	11438682
Intra	FNBP1	Q96RU3	TNKS	Homo sapiens	O95271	Anti Bait CoIP	14596906
Intra	FNBP1	Q96RU3	TNKS	Homo sapiens	O95271	IF	14596906
Intra	FNBP1	Q96RU3	FNBP1	Homo sapiens	Q96RU3	Solution Sedimentation	17512409
Intra	FNBP1	Q96RU3	FNBP1L	Homo sapiens	Q5T0N5	Anti Tag CoIP	35271311
Intra	FNBP1	Q96RU3	FNBP1	Homo sapiens	Q96RU3	Anti Tag CoIP	15252009
Intra	FNBP1	Q96RU3	FASLG	Homo sapiens	P48023	Anti Tag CoIP	16318909
Intra	FNBP1	Q96RU3	DNM2	Homo sapiens	P50570	Pull Down	15252009
Intra	FNBP1	Q96RU3	FNBP1	Homo sapiens	Q96RU3	X-Ray Diffraction	17512409
Intra	FNBP1	Q96RU3	DNM1	Homo sapiens	Q05193	Pull Down	15252009
Intra	FNBP1	Q96RU3	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	15252009
Intra	FNBP1	Q96RU3	FASLG	Homo sapiens	P48023	Anti Bait CoIP	16318909
Intra	FNBP1	Q96RU3	DNM2	Homo sapiens	P50570	Fluorescence	15252009
Intra	FNBP1	Q96RU3	FASLG	Homo sapiens	P48023	Pull Down	16318909
Intra	FNBP1	Q96RU3	DNM3	Homo sapiens	Q9UQ16	Fluorescence	15252009
Intra	FNBP1	Q96RU3	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Cross	FNBP1	Q96RU3	Inpp5d	Rattus norvegicus	P97573	Pull Down	26751515

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Frank-Ter Haar Syndrome	Ter Haar Syndrome Borrone Dermatocardioskeletal Syndrome FTHS Autosomal Recessive Melnick-Needles Syndrome Borrone Di Rocco Crovato Syndrome Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay Melnick-Needles Syndrome, Autosomal Recessive, Formerly Frank Ter Haar Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05016	FNBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05017	FNBP1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FNBP1	RGD	RGD:621350
Felis catus	FNBP1	VGNC	VGNC:102927
Mus musculus	FNBP1	MGD	MGI:109606
Bos taurus	FNBP1	VGNC	VGNC:29059
Macaca mulatta	FNBP1	VGNC	VGNC:72520
Canis familiaris	FNBP1	VGNC	VGNC:40924
Others	FNBP1	NCBI