1. Gene
  2. TNKS - tankyrase Gene

TNKS - tankyrase Gene

Homo sapiens

Also known as TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a

Gene ID: 8658 | Gene type: protein coding

About TNKS

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,555,912-9,782,346 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 279 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNKS Products(3)

mRNA Protein Name
XM_011543846.4 XP_011542148.1 poly [ADP-ribose] polymerase tankyrase-1 isoform X2
NM_003747.3 NP_003738.2 poly [ADP-ribose] polymerase tankyrase-1
XM_011543845.4 XP_011542147.1 poly [ADP-ribose] polymerase tankyrase-1 isoform X1

TNKS Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (186 - 279)

Ank

Ank: Ankyrin repeat (283 - 312)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (339 - 431)

Ank

Ank: Ankyrin repeat (436 - 465)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (526 - 618)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (654 - 747)

Ank_4

Ank_4: Ankyrin repeats (many copies) (752 - 789)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (809 - 899)

Ank_4

Ank_4: Ankyrin repeats (many copies) (905 - 943)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1030 - 1086)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (1111 - 1309)

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  • 1200
  • 1327 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-1

ADP-ribosyltransferase diphtheria toxin-like 5

TANK1

TNKS-1

TRF1-interacting ankyrin-related ADP-ribose polymerase 1

poly [ADP-ribose] polymerase 5A

protein poly-ADP-ribosyltransferase tankyrase-1

tankyrase I

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

tankyrase-1

Related Diseases

Diseases Alias
Chromosome 2q31.2 Deletion Syndrome
Cherubism

CRBM

Familial Benign Giant-Cell Tumor Of The Jaw

Familial Fibrous Dysplasia Of Jaw

Familial Multilocular Cystic Disease Of The Jaws

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNKS RGD RGD:1308784
Felis catus TNKS VGNC VGNC:66421
Mus musculus TNKS MGD MGI:1341087
Canis familiaris TNKS VGNC VGNC:47681
Macaca mulatta TNKS VGNC VGNC:78601
Bos taurus TNKS VGNC VGNC:36184
Others TNKS NCBI