TNKS - tankyrase Gene

Also Known as TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8658

About TNKS

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,555,912-9,782,346 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 279 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNKS Products (3)

mRNA Protein Name
XM_011543846.4 XP_011542148.1 poly [ADP-ribose] polymerase tankyrase-1 isoform X2
NM_003747.3 NP_003738.2 poly [ADP-ribose] polymerase tankyrase-1
XM_011543845.4 XP_011542147.1 poly [ADP-ribose] polymerase tankyrase-1 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
9822378 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
9822378 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
26373281 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9822378 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
18436240 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP
IMP: Inferred from mutant phenotype
26373281 GOA
involved in negative regulation of telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in negative regulation of telomeric DNA binding IDA
IDA: Inferred from direct assay
9822378 GOA
involved in negative regulation of telomeric DNA binding IMP
IMP: Inferred from mutant phenotype
25939383 GOA
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17026964 GOA
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17026964 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19759537 GOA
involved in positive regulation of telomere capping IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in positive regulation of telomere maintenance via telomerase IDA
IDA: Inferred from direct assay
12782650 GOA
involved in positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
11739745 GOA
involved in positive regulation of telomere maintenance via telomere lengthening IDA
IDA: Inferred from direct assay
12782650 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19245366 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
21478859 GOA
involved in protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
15133513 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
9822378 GOA
involved in protein poly-ADP-ribosylation IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19759537 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22864114 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
9822378 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
16076287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (186 - 279)

Ank

Ank: Ankyrin repeat (283 - 312)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (339 - 431)

Ank

Ank: Ankyrin repeat (436 - 465)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (526 - 618)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (654 - 747)

Ank_4

Ank_4: Ankyrin repeats (many copies) (752 - 789)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (809 - 899)

Ank_4

Ank_4: Ankyrin repeats (many copies) (905 - 943)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1030 - 1086)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (1111 - 1309)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1327 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-1

  • ADP-ribosyltransferase diphtheria toxin-like 5

  • TANK1

  • TNKS-1

  • TRF1-interacting ankyrin-related ADP-ribose polymerase 1

  • poly [ADP-ribose] polymerase 5A

  • protein poly-ADP-ribosyltransferase tankyrase-1

  • tankyrase I

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

  • tankyrase-1

TNKS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNKS O95271 FNBP1 Homo sapiens Q96RU3
Anti Tag CoIP
14596906
Intra
TNKS O95271 FNBP1 Homo sapiens Q96RU3
Y2H
14596906
Intra
TNKS O95271 UBASH3B Homo sapiens Q8TF42
Validated Y2H
32296183
Intra
TNKS O95271 TNKS1BP1 Homo sapiens Q9C0C2
Pull Down
12080061
Cross
TNKS O95271 Axin1 Mus musculus O35625
Anti Tag CoIP
19759537
Intra
TNKS O95271 DISC1 Homo sapiens Q9NRI5
Y2H
17043677
Intra
TNKS O95271 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
TNKS O95271 TERF1 Homo sapiens P54274
Pull Down
12080061
Intra
TNKS O95271 TERF1 Homo sapiens P54274
Anti Tag CoIP
20696165
Intra
TNKS O95271 ADPRS Homo sapiens Q9NX46
Validated Y2H
32296183
Intra
TNKS O95271 HIF1AN Homo sapiens Q9NWT6
Enzymatic Study
21251231
Intra
TNKS O95271 TCL1A Homo sapiens P56279
Validated Y2H
32296183
Intra
TNKS O95271 OARD1 Homo sapiens Q9Y530
Validated Y2H
32296183
Intra
TNKS O95271 CENPJ Homo sapiens Q9HC77
Anti Tag CoIP
22699936
Intra
TNKS O95271 CENPJ Homo sapiens Q9HC77
IF
22699936
Cross: Cross-species interaction Intra: Intraspecies interaction

TNKS Antibodies

Cat. No. Product Name Application Reactivity
HY-P87112 TNKS1 Antibody (YA6805) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Chromosome 2q31.2 Deletion Syndrome
Cherubism

  • CRBM

  • Familial Benign Giant-Cell Tumor Of The Jaw

  • Familial Fibrous Dysplasia Of Jaw

  • Familial Multilocular Cystic Disease Of The Jaws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108845 Tenecteplase Inhibitor 95.00% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (68)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-13990 NVP-TNKS656 99.68% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-147316 TP-5801 Inhibitor 98.55% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 96.07% Unkown
HY-153996 CT1113 99.61% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.55% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-117700 TNKS-IN-2 Inhibitor / Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-155246 PARP1-IN-15 / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14839 TNKS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14840 Tnks Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14841 Tnks Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-10893 TNK-651 Inhibitor / Unkown
HY-118731 TNK-6123 Activator / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-180867 TNKS modulator-1 / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNKS RGD RGD:1308784
Felis catus TNKS VGNC VGNC:66421
Mus musculus TNKS MGD MGI:1341087
Canis familiaris TNKS VGNC VGNC:47681
Macaca mulatta TNKS VGNC VGNC:78601
Bos taurus TNKS VGNC VGNC:36184
Others TNKS NCBI