1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. Tankyrase-IN-2

Tankyrase-IN-2 

Cat. No.: HY-126248
Handling Instructions

Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model.

For research use only. We do not sell to patients.

Tankyrase-IN-2 Chemical Structure

Tankyrase-IN-2 Chemical Structure

CAS No. : 1588870-36-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model[1].

IC50 & Target

IC50: 10 nM (TNKS1), 7 nM (TNKS2), 710 nM (PARP1)[1]

In Vitro

Tankyrase-IN-2 (1-10000 nM; 24 hours) leads to a dose-dependent increase of tankyrase protein abundance with an EC50 of 320 nM in DLD1 cells. This is in the same potency range as the value for axin2 increase (EC50=319 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.30

Formula

C₁₇H₁₄F₂N₂O₂

CAS No.
SMILES

O=C1NC(C2=CC=C(C(C)(O)C)C=C2)=NC3=C1C=C(F)C=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (263.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1616 mL 15.8078 mL 31.6156 mL
5 mM 0.6323 mL 3.1616 mL 6.3231 mL
10 mM 0.3162 mL 1.5808 mL 3.1616 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tankyrase-IN-2PARPpoly ADP ribose polymeraseselectiveoralcolorectalxenograftmodelInhibitorinhibitorinhibit

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Product Name:
Tankyrase-IN-2
Cat. No.:
HY-126248
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