1588870-36-3
Chemical Structure
Tankyrase-IN-2
- CAS No.: 1588870-36-3
- Formula:C17H14F2N2O2
- Molecular Weight:316.30
IUPAC Name: 6,8-difluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)quinazolin-4(3H)-one
InChIKey: FHBYLOWAINBPRJ-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CC=C(C(C)(O)C)C=C2)=NC3=C1C=C(F)C=C3F
Biological Activity: Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model[1].
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Tankyrase-IN-2 | 99.06% | Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model. | ||||||||||||||||||||
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Keywords
