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  3. CZC-25146 hydrochloride

CZC-25146 hydrochloride 

Cat. No.: HY-15800
Handling Instructions

CZC-25146 Hcl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.

For research use only. We do not sell to patients.

CZC-25146 hydrochloride Chemical Structure

CZC-25146 hydrochloride Chemical Structure

CAS No. : 1330003-04-7

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Description

CZC-25146 Hcl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. IC50 value: 4.76 nM/6.87 nM(wild type/G2019S LRRK2) [1] Target: LRRK2 CZC-25146displayed a very clean profile, it inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2 and PIP4K2C) with high potency, none of which have been classified as predictors of genotoxicity or hematopoietic toxicity. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro. CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and a clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.

Molecular Weight

525.00

Formula

C₂₂H₂₆ClFN₆O₄S

CAS No.

1330003-04-7

SMILES

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2F)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CZC-25146CZC25146CZC 25146LRRK2Leucine-rich repeat kinase 2Inhibitorinhibitorinhibit

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CZC-25146 hydrochloride
Cat. No.:
HY-15800
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