1. Cell Cycle/DNA Damage
    Epigenetics
    Stem Cell/Wnt
  2. PARP
    β-catenin
  3. WIKI4

WIKI4 

Cat. No.: HY-16910 Purity: 99.77%
Handling Instructions

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.

For research use only. We do not sell to patients.

WIKI4 Chemical Structure

WIKI4 Chemical Structure

CAS No. : 838818-26-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 372 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE WIKI4

    WIKI4 purchased from MCE. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in protein level.

    WIKI4 purchased from MCE. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in mRNA level.
    • Biological Activity

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    Description

    WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM[3].

    IC50 & Target[2]

    TNKS2

    26 nM (IC50)

    In Vitro

    WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling[1].
    WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2[1].

    Cell Viability Assay[1]

    Cell Line: DLD1 cells
    Concentration: 100 nM, 1 μM
    Incubation Time: 6 days
    Result: Inhibited growth of DLD1 cells.

    Western Blot Analysis[1]

    Cell Line: DLD1 cells
    Concentration: 1 μM
    Incubation Time: 2 hours,4 hours,6 hours, or 24 hours
    Result: Significantly increased the steady-state abundance of AXIN1 and AXIN2.
    Molecular Weight

    521.59

    Formula

    C₂₉H₂₃N₅O₃S

    CAS No.

    838818-26-1

    SMILES

    O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9172 mL 9.5861 mL 19.1721 mL
    5 mM 0.3834 mL 1.9172 mL 3.8344 mL
    10 mM 0.1917 mL 0.9586 mL 1.9172 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    WIKI4WIKI 4WIKI-4PARPβ-cateninpoly ADP ribose polymerase Beta cateninInhibitorinhibitorinhibit

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    Product name:
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    Cat. No.:
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