1. Cell Cycle/DNA Damage Epigenetics Stem Cell/Wnt
  2. PARP β-catenin
  3. WIKI4

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.

For research use only. We do not sell to patients.

WIKI4 Chemical Structure

WIKI4 Chemical Structure

CAS No. : 838818-26-1

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 91 In-stock
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10 mg USD 121 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.  [Abstract]

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in mRNA level.

    WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.  [Abstract]

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in protein level.
    • Biological Activity

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    • Customer Review

    Description

    WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM[3].

    IC50 & Target[2]

    TNKS2

    26 nM (IC50)

    In Vitro

    WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling[1].
    WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: DLD1 cells
    Concentration: 100 nM, 1 μM
    Incubation Time: 6 days
    Result: Inhibited growth of DLD1 cells.

    Western Blot Analysis[1]

    Cell Line: DLD1 cells
    Concentration: 1 μM
    Incubation Time: 2 hours,4 hours,6 hours, or 24 hours
    Result: Significantly increased the steady-state abundance of AXIN1 and AXIN2.
    Molecular Weight

    521.59

    Formula

    C29H23N5O3S

    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9172 mL 9.5861 mL 19.1721 mL
    5 mM 0.3834 mL 1.9172 mL 3.8344 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Purity & Documentation

    Purity: 99.93%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9172 mL 9.5861 mL 19.1721 mL 47.9304 mL
    5 mM 0.3834 mL 1.9172 mL 3.8344 mL 9.5861 mL
    10 mM 0.1917 mL 0.9586 mL 1.9172 mL 4.7930 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    Product Name:
    WIKI4
    Cat. No.:
    HY-16910
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