TNKS1/2-IN-1
Based on 1 Customer Validation
TNKS1/2-IN-1 (Example 4) is a TNKS1 and TNKS2 inhibitor, with pIC50 values of 8.2 or 7.3 against TNKS1, and 7.1 or 7.7 against TNKS2. TNKS1/2-IN-1 inhibits the enzymatic activities of TNKS1 and TNKS2. TNKS1/2-IN-1 is applicable for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 1498300-31-4
- Formula: C26H23F4N3O4
- Molecular Weight:517.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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TNKS1 8.2 or 7.3 (pIC50) |
TNKS2 7.1 or 7.7 (pIC50) |
TNKS1/2-IN-1 potently inhibits TNKS1 binding in a fluorescence polarization biochemical assay with a pIC50 of 8.2 and inhibits TNKS2 binding with a pIC50 of 7.1[1].
TNKS1/2-IN-1 inhibits TNKS1 binding in an HTRF biochemical assay with a pIC50 of 7.3 and inhibits TNKS2 binding with a pIC50 of 7.7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1498300-31-4
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Appearance Solid
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Molecular Weight 517.47
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Formula C26H23F4N3O4
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Color White to off-white
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SMILES
O=C(N1C[C@H]2CC[C@H](C(O)=O)CC2)N(CC3=CC=CC(C(F)(F)F)=C3C#N)C4=CC=C(F)C(C)=C4C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)