2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TNKS1/2-IN-1

TNKS1/2-IN-1 (Example 4) is a TNKS1 and TNKS2 inhibitor, with pIC50 values of 8.2 or 7.3 against TNKS1, and 7.1 or 7.7 against TNKS2. TNKS1/2-IN-1 inhibits the enzymatic activities of TNKS1 and TNKS2. TNKS1/2-IN-1 is applicable for cancer research.

For research use only. We do not sell to patients.

TNKS1/2-IN-1

TNKS1/2-IN-1 Chemical Structure

CAS No. : 1498300-31-4

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Based on 1 publication(s) in Google Scholar

TNKS1/2-IN-1 Related Antibodies

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Description

TNKS1/2-IN-1 (Example 4) is a TNKS1 and TNKS2 inhibitor, with pIC50 values of 8.2 or 7.3 against TNKS1, and 7.1 or 7.7 against TNKS2. TNKS1/2-IN-1 inhibits the enzymatic activities of TNKS1 and TNKS2. TNKS1/2-IN-1 is applicable for cancer research[1].

IC50 & Target[1]

TNKS1

8.2 or 7.3 (pIC50)

TNKS2

7.1 or 7.7 (pIC50)

In Vitro

TNKS1/2-IN-1 potently inhibits TNKS1 binding in a fluorescence polarization biochemical assay with a pIC50 of 8.2 and inhibits TNKS2 binding with a pIC50 of 7.1[1].
TNKS1/2-IN-1 inhibits TNKS1 binding in an HTRF biochemical assay with a pIC50 of 7.3 and inhibits TNKS2 binding with a pIC50 of 7.7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNKS1/2-IN-1 Related Antibodies
Molecular Weight

517.47

Formula

C26H23F4N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@H]2CC[C@H](C(O)=O)CC2)N(CC3=CC=CC(C(F)(F)F)=C3C#N)C4=CC=C(F)C(C)=C4C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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TNKS1/2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS1/2-IN-11498300-31-4PARPpoly ADP ribose polymeraseTNKS2HTRF biochemical assayfluorescence polarization biochemical assayTNKS1cancersInhibitorinhibitorinhibit

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