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ADPRS - ADP-ribosylserine hydrolase Gene

Also Known as ARH3; ADPRHL2; CONDSIAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54936

About ADPRS

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,088,892-36,093,932 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

ADPRS Products (1)

mRNA	Protein	Name
NM_017825.3	NP_060295.1	ADP-ribosylhydrolase ARH3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP-ribosylserine hydrolase activity	IDA IDA: Inferred from direct assay	28650317	GOA
enables O-acetyl-ADP-ribose deacetylase activity	IDA IDA: Inferred from direct assay	17075046	GOA
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IDA IDA: Inferred from direct assay	30045870	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	30045870	GOA
enables poly(ADP-ribose) glycohydrolase activity	IDA IDA: Inferred from direct assay	17075046	GOA
enables poly(ADP-ribose) glycohydrolase activity	IMP IMP: Inferred from mutant phenotype	33769608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	30045870	GOA
involved in cellular response to superoxide	IMP IMP: Inferred from mutant phenotype	30401461	GOA
involved in peptidyl-serine ADP-deribosylation	IDA IDA: Inferred from direct assay	28650317	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34479984	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	34479984	GOA
located in nucleus	IDA IDA: Inferred from direct assay	30045870	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	30045870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADPRS Protein Structure

ADP_ribosyl_GH

0
100
200
300
363 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylhydrolase ARH3	ADP-ribose glycohydrolase ARH3

ADPRS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADPRS	Q9NX46	TNKS	Homo sapiens	O95271	Y2H Array	32296183
Intra	ADPRS	Q9NX46	TNKS	Homo sapiens	O95271	Y2H Prey Pooling	32296183
Intra	ADPRS	Q9NX46	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Array	32296183
Intra	ADPRS	Q9NX46	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures	CONDSIAS Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Autosomal Recessive Arh FHCL4 Autosomal Recessive Hypercholesterolemia Arh1 Arh2 Autosomal Recessive Hypercholesterolemia 1 Autosomal Recessive Hypercholesterolemia 2 Fhcb1 Fhcb2 Hypercholesterolemia, Autosomal Recessive, 1, Formerly Arh1, Formerly Fhcb1, Formerly Hypercholesterolemia, Autosomal Recessive, 2, Formerly Arh2, Formerly Fhcb2, Formerly Familial Autosomal Recessive Hypercholesterolemia Hypercholesterolemia, Familial, Autosomal Recessive Hypercholesterolemia, Familial, Type 4
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150508	MK-0159	Inhibitor	99.72%	Unkown
HY-146248B	TFMU-ADPr diammonium		98.78%	Unkown
HY-144987	RBN013209	Inhibitor	98.63%	Unkown
HY-171213	NB-3	Inhibitor	99.89%	Unkown
HY-173679	RBN012811		98.79%	Unkown
HY-134354A	pNP-ADPr disodium		98.08%	Unkown
HY-186178	CD38-IN-6	Inhibitor	99.96%	Unkown
HY-146248A	TFMU-ADPr triethylamine		97.26%	Unkown
HY-134261A	8-Br-ADPR disodium	Inhibitor	/	Unkown
HY-134261	8-Br-ADPR	Inhibitor	/	Unkown
HY-134354	pNP-ADPr		/	Unkown
HY-146248	TFMU-ADPr		/	Unkown
HY-181543	CVN14	Inhibitor	/	Unkown
HY-184021	A-8531	Inhibitor	/	Unkown
HY-184206	A-3190	Inhibitor	/	Unkown
HY-RS00407	ADPRS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W154247	IP6C	Inhibitor	/	Unkown
HY-134268	8-Br-7-CH-ADPR	Antagonist	/	Unkown
HY-137704	2′-Deoxy-ADPR	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADPRS	MGD	MGI:2140364
Macaca mulatta	ADPRS	VGNC	VGNC:106317
Felis catus	ADPRS	VGNC	VGNC:59652
Bos taurus	ADPRS	VGNC	VGNC:25691
Rattus norvegicus	ADPRS	RGD	RGD:1309068
Others	ADPRS	NCBI