ADPRS - ADP-ribosylserine hydrolase Gene

Homo sapiens

Also known as ARH3; ADPRHL2; CONDSIAS

Gene ID: 54936 | Gene type: protein coding

About ADPRS

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,088,892-36,093,932 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded Enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This Enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

ADPRS Products(1)

mRNA	Protein	Name
NM_017825.3	NP_060295.1	ADP-ribosylhydrolase ARH3

ADPRS Protein Structure

ADP_ribosyl_GH

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylhydrolase ARH3

ADP-ribose glycohydrolase ARH3

Related Diseases

Diseases

Alias

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150508	MK-0159	Inhibitor	99.72%	Unkown
HY-146248B	TFMU-ADPr diammonium		98.02%	Unkown
HY-146248A	TFMU-ADPr triethylamine		97.26%	Unkown
HY-134354	pNP-ADPr		/	Unkown
HY-134354A	pNP-ADPr disodium		99.93%	Unkown
HY-146248	TFMU-ADPr		/	Unkown
HY-RS00407	ADPRS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADPRS	MGD	MGI:2140364
Macaca mulatta	ADPRS	VGNC	VGNC:106317
Felis catus	ADPRS	VGNC	VGNC:59652
Bos taurus	ADPRS	VGNC	VGNC:25691
Rattus norvegicus	ADPRS	RGD	RGD:1309068

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