CVN14 

CVN14 is a potent, selective and brain-penetrant CD38 inhibitor with human IC₅₀ 19 nM, mouse IC₅₀ 2.4 nM. CVN14 binds uncompetitively to form a complex with CD38 and ADPR, and inhibits CD38 enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases^[1].

CVN14 potently inhibits human CD38 with an IC₅₀ of 19 nM and mouse CD38 with an IC₅₀ of 2.4 nM^[1].
CVN14 potently inhibits human CD38 activity in CHO-hCD38 cells with an IC₅₀ of 19 nM^[1].
CVN14 binds tightly to human CD38 with a K_d of 3.6 nM and a long dissociation half-life of 143 min^[1].
CVN14 has favorable in vitro permeability across MDR1-MDCK cell monolayers with an efflux ratio of 0.90^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVN14 (10 mg/kg; p.o.; single dose) shows a high distribution to the brain with Kp_uu,brain values greater than 0.3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

382.38

C₁₇H₂₁F₃N₆O

2925663-26-7

FC(F)(F)CN[C@H](CC1)CC[C@@H]1NC(C2=CC(C)=NC(N3C=NC=C3)=N2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stott AJ, et al. Discovery of Potent, Selective, and Brain-Penetrant Small Molecule CD38 Inhibitors. ACS Med Chem Lett. 2026 Jan 29;17(2):259-265.  [Content Brief]