2925663-26-7
2925663-26-7
Chemical Structure
CVN14
- CAS No.: 2925663-26-7
- Formula:C17H21F3N6O
- Molecular Weight:382.38
InChIKey: ITFCOIJVQXVUMM-JOCQHMNTSA-N
SMILES: FC(F)(F)CN[C@H](CC1)CC[C@@H]1NC(C2=CC(C)=NC(N3C=NC=C3)=N2)=O
Biological Activity: CVN14 is a potent, selective and brain-penetrant CD38 inhibitor with human IC50 19 nM, mouse IC50 2.4 nM. CVN14 binds uncompetitively to form a complex with CD38 and ADPR, and inhibits CD38 enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases[1].
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CVN14 | CVN14 is a potent, selective and brain-penetrant CD38 inhibitor with human IC50 19 nM, mouse IC50 2.4 nM. CVN14 binds uncompetitively to form a complex with CD38 and ADPR, and inhibits CD38 enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases. | |||||||||||||||||||||
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References
Keywords
