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Cat. No.: HY-156745

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DDa-1

DDa-1 is a potent BTK degrader (DC₅₀: 90 nM).
(Pink: Btk ligand (HY-107447); Blue: Cereblon ligand (HY-149934); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3036944-98-3
Formula: C₆₀H₇₇Cl₂N₁₃O₃S
Molecular Weight:1131.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

DDa-1 Chemical Structure

CAS No.: 3036944-98-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DDa-1 is a potent BTK degrader (DC₅₀: 90 nM)^[1]. (Pink: Btk ligand (HY-107447); Blue: Cereblon ligand (HY-149934); Black: linker).

All PROTACs Isoforms :

Chemical Information

CAS No. 3036944-98-3
Molecular Weight 1131.31
Formula C₆₀H₇₇Cl₂N₁₃O₃S
SMILES

O=C(N1CCN(C2=CC=C3C(N=C(C4(C5=CC=C(Cl)C=C5)CCCCC4)N=C3NCCN)=C2)CC1)CCCCCCCN6CCC(OC7CCN(C8=CC(NC9=NC=C(C(NC%10=C(C)C=CC=C%10Cl)=O)S9)=NC(C)=N8)CC7)CC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schröder M, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15(1):275. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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DDa-1

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DDa-1 Related Classifications

HY-156745 Related Classifications