DCAF1 binder 1
Based on 1 Customer Validation
DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.77%
- No. CAS: 3053860-67-3
- Fòrmula: C28H35ClN6O
- Peso molecular:507.07
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3053860-67-3
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Appearance Solid
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Peso molecular 507.07
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Fòrmula C28H35ClN6O
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Color White to off-white
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SMILES
NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=C1C=CC(N5CCN(CC5)C(C)=O)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (98.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9721 mL | 9.8606 mL | 19.7211 mL | 49.3029 mL |
| 5 mM | 0.3944 mL | 1.9721 mL | 3.9442 mL | 9.8606 mL | |
| 10 mM | 0.1972 mL | 0.9861 mL | 1.9721 mL | 4.9303 mL | |
| 15 mM | 0.1315 mL | 0.6574 mL | 1.3147 mL | 3.2869 mL | |
| 20 mM | 0.0986 mL | 0.4930 mL | 0.9861 mL | 2.4651 mL | |
| 25 mM | 0.0789 mL | 0.3944 mL | 0.7888 mL | 1.9721 mL | |
| 30 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6434 mL | |
| 40 mM | 0.0493 mL | 0.2465 mL | 0.4930 mL | 1.2326 mL | |
| 50 mM | 0.0394 mL | 0.1972 mL | 0.3944 mL | 0.9861 mL | |
| 60 mM | 0.0329 mL | 0.1643 mL | 0.3287 mL | 0.8217 mL | |
| 80 mM | 0.0247 mL | 0.1233 mL | 0.2465 mL | 0.6163 mL |
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